Value of novel coronavirus vaccination for patients on maintenance hemodialysis and COVID-19
Objective To investigate the effects of vaccination against the novel coronavirus on the severity of corona virus disease 2019(COVID-19)in patients on maintenance hemodialysis(MHD).Methods Clinical data of 166 patients with end-stage renal disease who were on MHD and COVID-19 admitted to the Department of Nephrology of Fuyang People's Hospital affiliated with Anhui Medical University from December 2022 to January 2023 were retrospectively analyzed.Based on vaccination status,the group was divided into the unvaccinated group(0 vaccination)and the vaccinated group(≥2 vaccinations).Clinical characteristics and short-term prognosis were compared between the two groups,and logistic regression models were applied to analyze the independent risk factors for the increased risk of hospitalization and seri-ous disease.Results Among the 166 patients with MHD and COVID-19,91 cases(54.8％)were in the unvaccinated group and 75cases(45.2％)were vaccinated.The proportion of age and smoking was higher in the unvaccinated group than in the vaccinated group(P<0.05).After infection with novel coronavirus pneumonia,patients had a variety of clinical manifestations,with fever(73.1％),malaise(65.6％),and loss of appetite(57.5％)being the most common.The proportion of patients using hormones,centralized oxygen,hospitalization,and severe disease was significantly reduced and the proportion of cured patients was significantly increased in the inoculated group(P<0.05).Vaccination reduces the risk of hospitalization(OR=0.364,95％CI:0.147～0.901)and severe disease(OR=0.182,95％CI:0.037～0.901)in patients with MHD.Diabetes mellitus and coronary atherosclerotic heart disease(CHD)are independent risk factors hospitalization and readmission in patients with MHD combined with COVID-19.Age is an independent risk factor for increased risk of severe disease.Conclusions The clinical manifestations of COVID-19 in patients with end-stage renal disease receiving MHD are diverse.The risk of hospitalization and severe disease in patients with diabetes and coronary heart disease is increased,and age is an independent risk factor for increased risk of severe disease.Vaccination can re-duce the risk of hospitalization and severe disease.
万方数据
维普
