Association of serum HLA-E and HLA-G expression with disease progression and post-treatment recurrence in patients with HPV infection-associated CIN
Objective To investigate the expression and clinical significance of human leukocyte antigen E(HLA-E)and human leu-kocyte antigen G(HLA-G)in serum of patients with cervical intraepithelial neoplasia(CIN)associated with human papillomavirus(HPV)infec-tion.Methods A total of 120 cases of CIN patients with HPV infection treated in Hebei China Petroleum Central Hospital from June 2021 to December 2021 were selected as the observation group,and 60 cases of CIN patients without HPV infection in the same period were selected as the control group,the expressions of HLA-E and HLA-G in serum of the two groups were detected,and the relationship between the expres-sions of HLA-E and HLA-G in serum and the clinical data of patients and postoperative recurrence was analyzed.Results The level of serum HLA-E and HLA-G in the observation group was(75.59±18.28)pg/mL and(30.20±9.92)ng/mL,respectively,which was significantly higher than that in the control group(P<0.05).The level of serum HLA-E and HLA-G in patients with CIN grade II/Ⅲ was(83.33±13.90)pg/mL and(34.54±7.18)ng/mL,respectively,which was significantly higher than that in patients with CIN grade Ⅰ(P<0.05).The serum HLA-E and HLA-G level in patients with high-risk HPV infection in the observation group was(78.82±17.70)pg/mL and(32.23±9.43)ng/mL,respec-tively,which was significantly higher than that in patients with low-risk HPV infection(P<0.05).The expression of HLA-E and HLA-G in se-rum of the observation group was positively correlated with CIN grade(P<0.05).Serum HLA-E and HLA-G in patients with recurrence one week after operationwas(68.32±8.73)pg/mL and(24.43±5.58)ng/mL,respectively,which was significantly higher than that in patients with-out recurrence(P<0.05).Conclusion Serum HLA-E and HLA-G expressions in patients with CIN associated with HPV infection are posi-tively correlated with CIN grade,along with postoperative recurrence.
万方数据
维普
