Efficacy and safety analysis of calcitriol combined with calcium carbonate capsule in the treatment of diabetic osteoporosis
Objective To analyze the effects of calcitriol combined with calcium carbonate capsules on the efficacy,bone mineral den-sity,electrolyte metabolism and safety of patients with diabetic osteoporosis(DOP).Methods A total of 120 DOP patients admitted to the En-docrinology Department of Chizhou People's Hospital between January 2021 and May 2022 were selected as the study objects,who were di-vided into control group(n=60)and observation group(n=60)according to random number table method.The control group was given calcium carbonate capsule treatment,and the observation group was given calcitriol combined with calcium carbonate capsule treatment.The efficacy of the two groups after treatment was compared.The bone mineral density and electrolyte metabolism were compared between the two groups be-fore and after treatment.The drug safety during treatment was compared between the two groups.Results The total effective rate of the obser-vation group was higher than that of the control group(95.00%vs 83.33%)(P<0.05),and the total incidence of side effects was not statistically significant(3.33%vs 3.33%)(P=1.000).Compared with the control group,the differences of bone mineral density(BMD),blood Ca and P in the femoral trochanter,Wards triangle,neck of femur and lumbar vertebra L1~4 before and after treatment in the observation group were larger(P<0.05).Conclusions Calcitriol combined with calcium carbonate capsule can improve the curative effect of DOP patients,increase bone density and correct electrolyte metabolism level,safety and reliability.
Diabetic osteoporosisCalcitriolCalcium carbonate capsuleBone mineral densityMetabolism of electrolytes