Relationship between IL-6/IL-10 ratio and prognosis of severe pneumonia patients based on propensity score matching
Objective To explore the relationship between the ratio of interleukin-6(IL-6)/interleukin-10(IL-10)and the prognosis of patients with severe pneumonia(SP)by propensity score matching(PSM).Methods A total of 550 pneumonia patients admitted to Shijia-zhuang People's Hospital from May 2016 to June 2022 were selected as the research subjects,of which 450 patients with SP were in the SP group,100 patients with mild pneumonia were in the mild group,and 100 healthy people with physical examination were regarded as the healthy group.The levels of IL-6,IL-10 and the ratio of IL-6/IL-10 in the mild group,SP group and healthy group were compared,taking the median of IL-6/IL-10 ratio(0.96)of healthy subjects during physical examination as the boundary,SP patients were grouped into low IL-6/IL-10 ratio group(n=76)and high IL-6/IL-10 ratio group(n=374),then the clinical indicators and survival of SP patients were compared between the two groups.Propensity score matching(PSM)was used to balance the differences in other clinical indicators between the two groups of SP pa-tients,after PMS,the survival of low IL-6/IL-10 ratio group(n=75)and high IL-6/IL-10 ratio group(n=75)was compared;COX regression model was used to analyze the relationship between the ratio of IL-6/IL-10 after PMS and the prognosis of SP patients.Results The levels of serum IL-6,IL-10 and the ratio of IL-6/IL-10 in the SP group were higher than those in the mild group and the healthy group(P<0.05),and those inthe mild group were higher than those in the healthy group(P<0.05).Before PSM,patients in the high IL-6/IL-10 ratio group were treated with antibiotics longer than those in the low IL-6/IL-10 ratio group(P<0.05),and the ratio of mechanical ventilation and death rate were higher than those in the low IL-6/IL-10 ratio group(P<0.05),after PSM,the death rate of patients in the high IL-6/IL-10 ratio group was higher than that in the low IL-6/IL-10 ratio group(P<0.05).The ratio of IL-6/IL-10 was an independent risk factor for the prognosis of SP patients(P<0.05).Conclusion The ratio of IL-6/IL-10 in SP patients is higher.After balancing the confounding factors by PMS,the ratio of IL-6/IL-10 is still an independent risk factor for evaluating the prognosis of SP patients.
万方数据
维普
