Expression level and clinical significance of galectin-3 in serum of patients with bipolar disorder
Objective To investigate the expression level and clinical significance of galectin-3 in serum of patients with bipolar disor-der.Methods A total of 102 patients with bipolar disorder treated in Zigong Mental Health Center from January 2021 to July 2022 were se-lected as the observation group,then with the use of the clinical global impression scale(CGI-S)scores,they were divided into mild bipolar dis-order group of 40 patients,moderate bipolar disorder group of 34 patients,and severe bipolar disorder group of 28 patients.The patients were categorized according to their seizure status into a depressive seizure group of 46 cases,a manic seizure group of 35 cases and a mixed seizure group of 21 cases.Another 105 healthy check-up volunteers in the same period were used as the control group.Enzyme-linked immunosorbent assay(ELISA)was used to detect the level of serum galectin-3 in subjects.Spearman method was applied to analyze the correlation between se-rum galectin-3 level and CGI-S scores in patients.Multifactor logistic regression analysis was conducted on the factors influencing the occur-rence of bipolar disorder.ROC curve was employed to analyze the diagnostic value of serum galectin-3 level in patients.Results Compared with the control group,the serum galectin-3 level in the observation group was obviously higher(P<0.05).Serum galectin-3 levels of patients in the severe bipolar disorder patient group were higher than those in the moderate bipolar disorder patient group and the mild bipolar disorder pa-tient group,serum galectin-3 levels of patients in the moderate bipolar disorder patient group were higher than those in the mild bipolar disor-der patient group,and the difference was statistically significant(P<0.05).Patients in the mixed episode group had significantly higher galectin-3 levels than those in the manic and depressive episode groups,and the difference was statistically significant(P<0.05),serum galectin-3 level in patients with bipolar disorder was positively correlated with CGI-S score(r=0.435,P<0.001).Galectin-3 was a risk factor for bipolar disorder(P<0.05),the area under the ROC curve(AUC)of serum galectin-3 level in the diagnosis of bipolar affective disorder was 0.916.Conclusion The serum galectin-3 level in patients with bipolar affective disorder is elevated,which is related to the severity of the disease,and can better diagnose bipolar disorder.
Bipolar affective disorderGalectin-3Diagnostic value
万方数据
维普
