The value of combined detection of serum carcinoembryonic antigen, interferon, and interleukin-8 in predicting the prognosis of lung cancer
Objective To explore the value of the combination of serum carcinoembryonic antigen (CEA), interferon-γ (IFN-γ), and interleukin-8 (IL-8) in the prognosis of lung cancer. Methods Eighty lung cancer patients admitted to Renhe Hospital of Baoshan District, Shanghai from January 2016 to August 2018 were collected as the study subjects; in addition, 80 healthy physical examination who underwent health checks in our hospital were collected as the control group, then the serum levels of CEA, IFN-γ, and IL-8 were compared between the two groups.The serum levels of CEA, IFN-γ, and IL-8 were compared among lung cancer patients with different stages, pathological types, and prognosis. The patients were followed up for five years, and their survival was recorded. The patients were divided into good prognosis group (56cases) and poor prognosis group (24 cases).The prognostic survival rates of lung cancer patients with different serum CEA, IFN-γ and IL-8 levels were compared. ROC curve was applied to analyze the predictive value of serum CEA, IFN-γ, and IL-8 for poor prognosis in lung can-cer patients. Paired sample t-test was applied to compare changes in serum CEA, IFN-γ, and IL-8 levels in lung cancer patients before and af-ter treatment. Results The serum CEA and IL-8 levels in the lung cancer group were higher than those in the control group, while the IFN-γ level was lower than that in the control group (P<0.05). Compared with TNMⅢ patients, the serum levels of CEA and IL-8 in TNM IV patients increased, while IFN-γ level decreased (P<0.05). The 5-year survival rate of patients with low CEA level was higher than that of patients with high CEA level; The 5-year survival rate of patients with low IFN-γ level was lower than that of patients with high IFN-γ level; The 5-year survival rate of patients with low level of IL-8 was higher than that of patients with high level of IL-8. The area under the curve (AUC) of serum CEA, IFN-γ, and IL-8 for evaluating poor prognosis in lung cancer patients was 0.817 (95％ CI: 0.713～0.921), 0.818 (95％ CI: 0.727～0.910), and 0.781 (95％ CI: 0.654～0.907), respectively, and the AUC of the three combined tests was 0.917 (95％ CI: 0.843～0.990). Compared with the group with good prognosis, the group with poor prognosis showed an increase in serum CEA and IL-8 levels and a decrease in IFN-γ level (P<0.05). After treatment, the serum levels of CEA and IL-8 were lower than those before treatment, while the IFN-γ level was higher than that be-fore treatment (P < 0.05). Conclusions Serum CEA and IL-8 levels increase in lung cancer patients, while IFN-γ levels decrease. They are related to prognosis of patients and can be used an evaluation indicators for predicting poor prognosis in lung cancer patients.
万方数据
维普
