An examination of clinically relevant risk factors in patients with Wilson's disease combined with white matter lesions
Objective To investigate the clinically relevant risk factors for Wilson's disease(WD)patients with combined cerebral white matter lesions(WMLs).Methods Forty-three patients with WD combined with WMLs who were hospitalized in the Affiliated Hospital of Neurological Institute of Anhui University of Traditional Chinese Medicine between August 2022 and June 2023 were recruited as the study group,and 44 WD patients without WMLs hospitalized in the same period as the control group,then the clinical data of the two groups were retrospectively analyzed and studied.The differences in the general data of the two groups of patients,24 h urine copper,serum copper blue protein,serum iron,blood glucose,blood lipids and homocysteine,uric acid,creatinine and other clinical test indexes were compared,the risk factors related to WD combined with WMLs were analyzed with bicategory logistic regression analysis,the correlation between the 24 h urine copper and homocysteine before the treatment was observed with Spearman's correlation analysis.Results The homocysteine and 24 h urine copper before treatment were higher in the study group than in the control group,and the differences were statistically significant(P＜0.05),while the differences in serum copper blue protein,serum iron,blood glucose,blood lipids,and uric acid and creatinine were not statistically significant in the two groups(P＞0.05).Two-category logistic regression analysis showed that increased homocysteine was a risk factor for WD combined with WMLs(OR=1.105,95%CI:1.013～1.205,P=0.024).Conclusion Increased serum homocysteine is a risk factor for WD com-bined with WMLs.
Wilson's diseaseWhite matter lesionsHomocysteineUrine copperCopper blue proteinBlood glucoseBlood lipids
NETL
NSTL
万方数据
维普
