Correlation between dynamic changes of serum ferritin during pregnancy and its delivery outcomes
Objective To analyze the dynamic changes of serum ferritin(SF)levels during pregnancy and explore the relationship be-tween SF levels at different gestational weeks and delivery outcomes.Methods A total of 665 pregnant women who had regular prenatal checks and consecutive SF tests three times in the Eastern District of the First Affiliated Hospital of Anhui Medical University from January 2021 to August 2023,and delivered at the same hospital,were selected as the research subjects.The dynamic changes of SF levels during preg-nancy were analyzed.Linear regression model and restricted cubic spline analysis were used to analyze the correlation between SF levels at dif-ferent gestational weeks and delivery outcomes.A group-based trajectory model was constructed to describe the relationship between the dy-namic changes of SF levels and delivery outcomes.Results With the increase of gestational week,the SF levels showed a decreasing trend,and the rate of iron deficiency increased.Linear correlation analysis showed that there was no statistically significant association between SF levels at 8～16 weeks and 16～24 weeks of pregnancy and delivery outcomes(P>0.05);however,SF levels at 24～32 weeks of pregnancy were negatively correlated with newborn length(β=-0.009,95%CI:-0.015～0.003),newborn birth weight(β=-3.331,95%CI:-5.201～-1.461),and gestational week at delivery(β=-0.013,95%CI:-0.019～-0.008).Restricted cubic spline curve fitting showed that there was no statisti-cally significant correlation between SF levels at 8～16 weeks and 16～24 weeks of pregnancy and delivery outcomes(Poverall>0.05),while SF lev-els at 24～32 weeks of pregnancy were linearly and positively correlated with gestational week at delivery and newborn length(Poverall<0.05,Pnon-linear>0.05),and non-linearly correlated with newborn birth weight(Poverall<0.05,Pnon-linear<0.05).The SF group-based trajectory model showed that the preterm birth rate in the group with rapid decrease in SF concentration was higher than that in the group with moderate de-crease and slow decrease in SF concentration(P<0.01),and there was no statistically significant correlation between the different SF change tra-jectories and newborn birth weight.Conclusion Increased SF levels at 24～32 weeks of pregnancy are associated with gestational week at de-livery,newborn length,and birth weight.Continuous decrease of SF levels during pregnancy is related to the increased risk of preterm birth.
Serum ferritinDelivery outcomesMultivariate linear regressionRestricted cubic splineGroup-based trajectory model
NETL
NSTL
万方数据
维普
