The predictive value of NLR combined with MPVLR for coronary artery lesions in Kawasaki disease
Objective To investigate the predictive value of the neutrophil-to-lymphocyte ratio(NLR)combined with mean platelet volume-to-lymphocyte ratio(MPVLR)for coronary artery lesions(CALs)in Kawasaki disease(KD).Methods We selected 264 KD patients admitted to the Pediatric Department of the First Affiliated Hospital of Anhui Medical University from January 2018 to January 2023.Based on echocardiographic results,the patients were categorized into the CALs group(n=34)and the non-CALs group(nCALs,n=230).We collected the clinical data and peripheral blood cell parameters,calculated NLR and MPVLR,compared the differences in various indicators between the two groups,and used binary logistic regression analysis to identify independent risk factors for KD with CALs.We applied receiver operating characteristic(ROC)curve analysis to evaluate the efficacy of NLR,MPVLR,and their combination in predicting CALs in KD.Results White blood cell(WBC)and platelet(PLT)counts,as well as NLR and MPVLR levels in the CALs group were significantly higher than those in the nCALs group,with statistically significant differences(P<0.05).Binary logistic regression analysis revealed that WBC(OR=1.236,95%CI:1.115～1.371,P<0.001),PLT(OR=1.004,95%CI:1.001～1.007,P=0.008),NLR(OR=1.091,95%CI:1.001～1.189,P=0.046),and MPVLR(OR=1.160,95%CI:1.008～1.336,P=0.038)were independent risk factors for CALs.The optimal cutoff value for NLR in predicting CALs was 3.93,with a sensitivity of 76.43%,specificity of 69.82%,and AUC of 0.762(95%CI:0.714～0.805,P<0.001).For MPVLR,the optimal cutoff value was 3.53,with a sensitivity of 72.69%,specificity of 62.83%,and AUC of 0.721(95%CI:0.671～0.767,P<0.001).The sensitivity and specificity of NLR combined with MPVLR in predicting CALs was 78.12%and 68.68%,respectively,with an AUC of 0.775(95%CI:0.728～0.817,P<0.001).Conclusion Peripheral blood cell parameters,particularly NLR and MPVLR,hold significant value in predicting CALs in KD.The combined efficacy of NLR and MPVLR in predicting CALs is superior.
Kawasaki diseaseCoronary artery lesionsNeutrophil-to-lymphocyte ratioMean platelet volume-to-lymphocyte ratio
NETL
NSTL
万方数据
维普
