Protein-energy wasting and its relationship with negative mood and sleep quality in maintenance hemodialysis patients
Objective To investigate the incidence of protein-energy wasting(PEW)and its relationship with negative mood and sleep quality in maintenance hemodialysis(MHD)patients.Methods A total of 150 patients receiving regular hemodialysis treatment in The Third Affiliated Hospital of Anhui Medical University from January 2022 to May 2023 wereincluded.Patients were divided into PEW group(n=52)and non-PEW group(n=98)using the diagnostic criteria of protein-energy wasting proposed by the international society of renal nutrition and metabolism(ISRNM).The differences in general data,laboratory indexes and human body data between the two groups were analyzed.Logistic regression analysis was used to explore PEW incidence and risk factors,and self-rating anxiety scale(SAS),self-rating depression scale(SDS),Pittsburgh sleep quality index(PSQI)were employed to assess the anxiety,depression and sleep quality of patients in the two groups,and the re-lationship between PEW and negative emotion and sleep quality were further explored.Results The PEW incidence of maintenance dialysis patients was 34.7%;the scores of SAS,SDS and PSQI in the PEW group were higher than those in the non-Pew group,with statistical signifi-cance(P<0.05).Multivariate logistic regression analysis showed that C-reactive protein(OR=1.053,95%CI:1.013～1.096)was PEW risk fac-tor,while middle upper arm circumference(OR=0.556,95%CI:0.371～0.834),high hemoglobin(OR=0.969,95%CI:0.944～0.995)were PEW protective factors.PEW was associated with the risk of negative mood and sleep quality.The risk of anxiety in the PEW group was 2.752 times that of the non-Pew group(95%CI:1.307～5.795,P=0.008),and the risk of depression in the PEW group was 3.387 times that of the non-Pew group(95%CI:1.371～8.371,P=0.008).The risk of sleep disorders in the PEW group was 2.939 times higher than that in the non-Pew group(95%CI:1.402～6.161,P=0.004).Conclusion The incidence of PEW is higher in maintenance hemodialysis patients,C-reactive protein is PEW risk factor,while upper middle arm circumference and high hemoglobin are PEW protective factors,PEW increases the risk of negative mood and sleep disorders in maintenance hemodialysis patients.
NETL
NSTL
万方数据
维普
