The pathological study of the effects of antitumor drugs on chronic radiation bowel injury
Objective To explore the effect of antitumor drugs on chronic radiation bowel injury tissues of cervical cancer from the per-spective of pathology.Methods The clinicopathological data of patients with chronic radiation bowel injury from cervical cancer in the First Affiliated Hospital of Anhui Medical University between August 2016 and April 2023 were retrospectively analyzed.The clinical symptoms of radiation bowel injury in 49 patients were scored and graded in severity according to the RTOG/EORTC scoring criteria.They were divided into the anti-angiogenic drug treatment group,no anti-angiogenic drug treatment group,and paclitaxel chemotherapy group and no paclitaxel che-motherapy group according to the drug treatment regimen.The degree of chronic radiation bowel injury in patients was assessed using a semi-quantitative scoring system for pathology,and the differences in microvessel count,stenosis count,stenosis proportion,total pathology score,ul-ceration,inflammation,edema,necrosis,and fibrosis indexes were compared between corresponding subgroups,respectively.Cox analysis was also used to analyze the independent risk factors for serious complications in patients with chronic radiation bowel injury.Results The ste-notic vessel count,stenotic vessel ratio,ulceration and inflammation in the antiangiogenic drug treatment group were higher than those in the no antiangiogenic drug treatment group,and the differences were statistically significant(all P<0.05);whereas the microvessel count and fibrosis in the antiangiogenic drug treatment group were lower than those in the no antiangiogenic drug treatment group,and the differences were statis-tically significant(all P<0.05).Comparison of pathological indexes between the paclitaxel chemotherapy group and the no-paclitaxel chemo-therapy group showed no statistically significant difference(P all>0.05).Cox multifactorial analysis showed that antiangiogenic drugs were not an independent risk factor for the occurrence of serious complications in patients with chronic radiation bowel injury(P>0.05).Conclusion Anti-angiogenic drugs exacerbated stenosis,ulceration and inflammation,but attenuated fibrosis in chronic radiation bowel injury tissues in cer-vical cancer.Paclitaxel drugs have no significant effect on chronic radiation bowel injury tissues in cervical cancer.
Cervical cancerChronic radiation bowel injuryAntitumor drugsPathological features
NETL
NSTL
万方数据
维普
