The predictive value of parental BMI combined with child birth weight and BMI in childhood asthma
Objective To investigate the potential association and predictive value between maternal BMI before pregnancy,maternal weight gain during pregnancy,birth weight,and childhood asthma.Methods A total of 1 760 children were selected from pediatric outpatient department of Hefei Second People's Hospital from September 2019 to January 2023,and divided into an asthma group(n=440)and a control group(n=1 320)according to whether they had asthma.Case-control studies were carried out,and their general clinical data were compared,and multivariate logistic regression was used to analyze the correlation between BMI before pregnancy,maternal weight gain during pregnancy,birth weight,BMI and asthma in children.The ROC curve was used to assess its predictive value.Results There were significant differences in BMI,gestational weight gain,birth weight,BMI and the proportion of mothers with asthma between the two groups(P<0.05).Multivariate lo-gistic regression analysis showed that paternal BMI(OR=1.006,95%CI:1.006～1.007),maternal preconception BMI(OR=2.107,95%CI:1.839～2.424),gestational weight gain of mothers(OR=3.970,95%CI:3.325～4.801),birth weight(OR=1.006,95%CI:1.006～1.007)and BMI(OR=1.427,95%CI:1.109～1.841)of children were independent risk factors for childhood asthma(P<0.05).ROC curve analysis showed that the AUC of the five risk factors of child birth weight,maternal weight gain during pregnancy,child BMI,maternal pre-pregnancy BMI and paternal BMI for the prediction of asthma was 0.960,which was significantly higher than that of the single test(0.826,0.893,0.562,0.827 and 0.718),respectively.The sensitivity and specificity of the combined assessment was 91.7%and 91.5%respectively,which were higher than those of the individual test(67.0%,85.7%,67.3%,78.4%and 58.2%;84.5%,83.7%,44.2%,90.2%,77.1%)respectively.Conclusion Parental BMI before preg-nancy,maternal weight gain during pregnancy,birth weight,and BMI are related to childhood asthma,and combined diagnosis has a higher pre-dictive value for childhood asthma.
AsthmaChildrenBody mass indexBirth weightGestational weight gain
NETL
NSTL
万方数据
维普
