Objective To investigate thetrajectories of cognitive level and negative mood in Breast cancer patients at different stages of neoadjuvant chemotherapy,and to analyze the correlation between the two variables.Methods A longitudinal study was conducted to investi-gate 99 breast cancer patients admitted to Chongqing University Cancer Hospital in August 2022 to January 2023 by using the FACT-Cog(Ver-sion 3)scale,word fluency test,wiring test type A,numerical breadth test,anxiety self-rating scale,and depression self-rating scale to dynami-cally assesses changes in cognition and mood in NAC(TP0),after NAC Cycle 1(TP1),before surgery(TP2),and the correlation between the two variables were analyzed.Results The cognitive level of TP0～TP2 decreased progressively during neoadjuvant chemotherapy(P<0.05),and the anxiety and depression levels of TP0～TP2 increased progressively(P<0.05),Pearson correlation analysis results showed that the cognitive level of neoadjuvant breast cancer patients was negatively correlated with anxiety and depression in the TP0 period(r=-0.443、-0.446),Cogni-tive level was negatively correlated with anxiety and depression during TP1(r=-0.488、-0.522).Cognitive level was negatively correlated with anxiety and depression during TP2(r=-0.580、-0.539).Conclusion Cognitive level of breast cancer patients during neoadjuvant chemo-therapy has a tendency to decline;cognitive ability is affected by negative emotions.
Breast cancerNeoadjuvant chemotherapyCognitive levelNegative emotionsChange trajectory
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