乳腺癌患者新辅助化疗期间认知水平与负性情绪的纵向研究
A longitudinal study of cognitive level and negative emotion in breast cancer patients during neoadjuvant chemotherapy
罗羽 1邓永春 1周俸名 1张欢1
作者信息
- 1. 400030 重庆沙坪坝 重庆大学附属肿瘤医院乳腺肿瘤中心
- 折叠
摘要
目的 探讨乳腺癌患者新辅助化疗(NAC)期间认知水平与负性情绪变化轨迹并分析二者相关性.方法 选取2022年8月至2023年1月重庆大学附属肿瘤医院入院的99例乳腺癌患者,采用FACT-Cog(Version 3)量表、词语流畅性测验、连线测验A型、数字广度测试、焦虑自评量表、抑郁自评量表进行纵向调查,在NAC前(TP0)、行NAC第1周期后(TP1),手术前(TP2)动态评估患者的认知水平、情绪的变化,使用Pearson相关性分析二者之间的相关性.结果 乳腺癌患者在NAC期间从TP0～TP2认知水平呈下降趋势(P＜0.05);TP0～TP2焦虑、抑郁水平呈先下降后上升趋势(P＜0.05);Pearson相关性分析结果显示,新辅助乳腺癌患者认知水平与焦虑、抑郁在TP0时期均呈负相关(r=-0.443、-0.446);认知水平与焦虑、抑郁在TP1时期均呈负相关(r=-0.488、-0.522),认知水平与焦虑、抑郁在TP2时期均呈负相关(r=-0.580、-0.539).结论 乳腺癌患者NAC期间认知水平呈下降趋势,认知能力受负性情绪的影响.
Abstract
Objective To investigate thetrajectories of cognitive level and negative mood in Breast cancer patients at different stages of neoadjuvant chemotherapy,and to analyze the correlation between the two variables.Methods A longitudinal study was conducted to investi-gate 99 breast cancer patients admitted to Chongqing University Cancer Hospital in August 2022 to January 2023 by using the FACT-Cog(Ver-sion 3)scale,word fluency test,wiring test type A,numerical breadth test,anxiety self-rating scale,and depression self-rating scale to dynami-cally assesses changes in cognition and mood in NAC(TP0),after NAC Cycle 1(TP1),before surgery(TP2),and the correlation between the two variables were analyzed.Results The cognitive level of TP0～TP2 decreased progressively during neoadjuvant chemotherapy(P<0.05),and the anxiety and depression levels of TP0～TP2 increased progressively(P<0.05),Pearson correlation analysis results showed that the cognitive level of neoadjuvant breast cancer patients was negatively correlated with anxiety and depression in the TP0 period(r=-0.443、-0.446),Cogni-tive level was negatively correlated with anxiety and depression during TP1(r=-0.488、-0.522).Cognitive level was negatively correlated with anxiety and depression during TP2(r=-0.580、-0.539).Conclusion Cognitive level of breast cancer patients during neoadjuvant chemo-therapy has a tendency to decline;cognitive ability is affected by negative emotions.
关键词
乳腺癌/新辅助化疗/认知水平/负性情绪/变化轨迹Key words
Breast cancer/Neoadjuvant chemotherapy/Cognitive level/Negative emotions/Change trajectory引用本文复制引用
基金项目
重庆市科卫联合医学科研面上项目(2023MSXM103)
重庆市沙坪坝区决策咨询与管理创新项目(jcd202269)
重庆市医药生物技术协会科研育苗项目(cmba2022kyymzkxmH0010)
出版年
2024
NETL
NSTL
万方数据