Analysis of risk factors for rheumatoid arthritis associated with essential hypertension
Objective To investigate the risk factors for rheumatoid arthritis associated with essential hypertension in patients.Meth-ods A retrospective analysis was performed to compare the clinical data of 711 rheumatoid arthritis patients admitted to the Rheumatology and Immunology Department of the First Affiliated Hospital of Anhui Medical University from June 2016 to November 2019.According to the presence or absence of essential hypertension,they were divided into the observation group(n=125)and the control group(n=586),and the dif-ferences in general data,disease-related indicators and drug use between the two groups were compared.The trend χ2 test was used to compare the prevalence of essential hypertensionamong rheumatoid arthritis patients with different ages,different disease duration,and different body mass index.Binary logistic regression analysis was used to analyze the risk factors of essential hypertension in rheumatoid arthritis patients.Re-sults There were significant differences in age,body mass index,course of disease,comorbid type 2 diabetes mellitus,and use of glucocorti-coids and hydroxychloroquine between the two groups.There were no statistically significant levels in disease activity score in 28 joints、metho-trexate、leflunomide and conventional disease modifying antirheumatic drugs use.The results of logistic regression analysis showed:older age(OR=1.056,95%CI:1.034～1.077,P<0.001),high body mass index(OR=1.120,95%CI:1.060～1.184,P<0.001),concomitant with type 2 diabe-tes mellitus(OR=3.012,95%CI:1.664～5.435,P<0.001),the use of glucocorticoid(OR=1.996,95%CI:1.238～3.215,P=0.005)were found to be risk factors for rheumatoid arthritis in the comorbid of essential hypertension.The use of hydroxychloroquine(OR=0.604,95%CI:0.389～0.937,P=0.024)was a protective factor for essential hypertension in patients with rheumatoid arthritis.Conclusions The prevalence of essen-tial hypertension in RA patients increases with age,body mass index and glucocorticoid use.The use of hydroxychloroquine may reduce the risk of these patients.
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