Clinical significance of chemokine CXCL2 in isolated polymyalgia rheumatica
Objective To study the clinical significance of the chemokine CXCL2 in isolated polymyalgia rheumatic(PMR)patients.Methods Serum samples were collected from 6 PMR patients who were selected for chemokine proteomic screening from the Chinese Clini-cal Trial Registry(ChiCTR 1800019715)established in our centre.In addition,serum samples were collected from another 22 PMR patients who were first diagnosed,18 patients with PMR after treatment remission,20 rheumatoid arthritis(RA)patients who were first diagnosed and 20 healthy individuals.Eenzyme-linked immunosorbent assay(ELISA)was used to determine the difference in the concentration of CXCL2 in the four groups,and the correlation between serum CXCL2 levels and PMR activity were studied.Results Chemokine proteomics screening showed significant differential expression of CXCL2 in six patients with primary diagnosis of PMR;ELISA validation demonstrated that the me-dian serum CXCL2 level in the PMR activity group was significantly lower than that in the PMR remission group(P=0.039),and also signifi-cantly lower than that in the RA activity group(P=0.006)and the healthy physical examination group(P=0.041);there was no significant corre-lation between serum CXCL2 levels in patients with PMR and activity parameters such as erythrocyte sedimentation rate,C-reactive protein,and polymyalgia rheumatica activity score(all P-values>0.05).ROC analysis showed that CXCL2 might be used in the diagnosis of PMR(AUC=0.709)and in the differential diagnosis with RA(AUC=0.750).Conclusions The chemokine CXCL2 plays a role in the development of PMR and may be used in the differential diagnosis with rheumatoid arthritis.
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