Application value of multimodal CMR in COVID-19 infection associated myocarditis
Objective To study the value of multimodal cardiac magnetic resonance imaging(CMR)in the diagnosis of COVID-19 as-sociated myocarditis.Methods From December 2022 to February 2023,67 patients with COVID-19 infection related myocarditis in Fuyang Second People's Hospital were selected as the observation group,and 15 healthy volunteers were selected as the control group.Both groups of subjects underwent multimodal CMR examination and were tested for creatine kinase isoenzyme(CK-MB)and lactate dehydrogenase(LDH)in blood.To compare the predictive efficacy of different CMR quantitative parameters on COVID-19 infection associated myocarditis was com-pared by calculating ROC curve.Pearson correlation analysis was used to analyze the correlation between quantitative parameters of multi-modal CMR,CK-MB,and LDH.Results The initial T1 value,left ventricular end systolic volume(LVESV),left ventricular end diastolic vol-ume(LVEDV),LDH,and CK-MB of the observation group were higher than those of the control group,while the relative peak signal intensity and area ratio under the myocardial perfusion curve were lower than those of the control group(P<0.05).LVESV,LVEDV,and initial T1 were positively correlated with CK-MB and LDH(r=0.764,0.653,0.701,0.802,all P<0.05),while the area ratio and relative peak signal intensity under the myocardial perfusion curve were negatively correlated with CK-MB and LDH(r=-0.411,-0.369).The AUC of initial T1 value,LVEDV,LVESV,myocardial perfusion,and relative peak signal intensity for diagnosing COVID-19 associated myocarditis was 0.921,0.692,0.711,0.701,and 0.716,respectively.The AUC of the combined detection of the above indicators was 0.943,and the sensitivity and specificity was 86.70%and 100.00%,respectively.Conclusions The quantitative and functional parameters of multimodal CMR have good clinical ap-plication value in the early assessment of COVID-19 infected myocarditis.
Cardiac magnetic resonance imagingQuantitative analysisCoronavirus disease 2019 infectionMyocarditis
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