汉防己甲素自微乳的研制
Preparation technology of the tetrandrine self-microemulsifying system
齐雪萍 1桂双英 2鲁传华 1刘鹏 1郭玉丽 1程斌 1彭代银3
作者信息
- 1. 安徽中医学院药学院
- 2. 安徽中医学院药学院;现代中药安徽省工程技术研究中心;安徽省"115"现代中药研发创新团队,安徽,合肥,230031
- 3. 现代中药安徽省工程技术研究中心;安徽省"115"现代中药研发创新团队,安徽,合肥,230031
- 折叠
摘要
目的 研究汉防己甲素自微乳的制备.方法 通过考察汉防己甲素在不同介质中的溶解度,采用伪三元相图法制备汉防己甲素自微乳,利用自微乳化效率和载药量考察,筛选最佳处方.结果 汉防己甲素自微乳化制剂的处方为:乳化剂OP-10:异丙醇:油酸:油酸乙酯=4:8:1.5:1.5.结论 汉防己甲素自微乳载药量为33.31 g·L-1,处方切实可行,性质稳定.
Abstract
Aim To explore the preparation technology of the tetrandrine self-microemulsifying drug delivery system (SMEDDS). Methods The equilibrium solubility of tetrandrine in different mediums was investigated. Tetrandrine self-microemulsion was prepared through the pseudo ternary phase diagram. The self-microemulsion formula was optimized by studying the self-microemulsifying efficiency and the satisfying solubility. Results The optimal self-microemulsion formula was composed of emulsifier OP,isopropyl alcohol and the compounds of oleic acid and ethyl oleate. The ratio of them was 4:8:1.5:1.5. Conclusion The optimal self-microemulsion formula is accurate and reliable. The satisfying solubility is 33.31 g·L-1 ,with good stability.
关键词
TET/伪三元相图/自微乳/载药量Key words
tetrandrine/pseudoternary phase diagram/self-microemulsifying system/satisfying solubility引用本文复制引用
出版年
2010
NETL
NSTL
维普
万方数据