Secreted phosphoprotein 1(SPP1),a member of the glycoprotein family,is extensively expressed in lung adenocarcinoma,gastric cancer,esophageal squamous cell carcinoma,and other tumor tissues,and possesses biomarker properties in a multitude of tu-mors.By interacting with ligands,SPP1 influences the downstream signaling pathway and impedes the tumor immune microenviron-ment,thereby facilitating the growth,invasion,and metastasis of various malignant tumors.SPP1 is also capable of mediating drug resis-tance in ovarian cancer and other forms of cancer.Additionally,SPP1 can also mediate drug resistance in ovarian cancer and hepatocel-lular carcinoma through the phosphoinositol 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway.Studies have demonstrated that SPP1 inhibitors can reverse tumor drug resistance and slow down tumor progression.SPP1 possesses the potential to be among the via-ble targets for the diagnosis and treatment of malignant tumors.This study reviews the progress of SPP1 gene research in malignant tu-mors.
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