The role of SPP1 gene in malignant tumors and its research progress
Secreted phosphoprotein 1(SPP1),a member of the glycoprotein family,is extensively expressed in lung adenocarcinoma,gastric cancer,esophageal squamous cell carcinoma,and other tumor tissues,and possesses biomarker properties in a multitude of tu-mors.By interacting with ligands,SPP1 influences the downstream signaling pathway and impedes the tumor immune microenviron-ment,thereby facilitating the growth,invasion,and metastasis of various malignant tumors.SPP1 is also capable of mediating drug resis-tance in ovarian cancer and other forms of cancer.Additionally,SPP1 can also mediate drug resistance in ovarian cancer and hepatocel-lular carcinoma through the phosphoinositol 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway.Studies have demonstrated that SPP1 inhibitors can reverse tumor drug resistance and slow down tumor progression.SPP1 possesses the potential to be among the via-ble targets for the diagnosis and treatment of malignant tumors.This study reviews the progress of SPP1 gene research in malignant tu-mors.
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