Relationship between the expression of serum IL-6R and IL-22 and the severity and clinical outcome of ulcerative colitis
Objective To explore the relationship between the expression of serum interleukin-6 receptor(IL-6R)and interleukin-22(IL-22)and the severity and clinical outcome of ulcerative colitis.Methods Two hundred and twelve patients with ulcerative colitis treated in Jianli People's Hospital from December 2017 to June 2022 were as research objects,according to the severity of their condi-tion,they were grouped into mild and severe group,according to the prognosis after 2 months of treatment,they were grouped into a good prognosis group and a poor prognosis group,enzyme linked immunosorbent assay(ELISA)was applied to detect IL-6R and IL-22 levels,and clinical data were collected from patients,Logistic regression was applied to analyze the related factors affected the progno-sis of patients with ulcerative colitis;receiver operating characteristic was drawn to predict the clinical diagnostic and predictive value of IL-6R and IL-22 for severity and prognosis of ulcerative colitis.Results Compared with the mild group[(11.10±1.21)ng/L,(50.24±6.35)ng/L],the serum levels of IL-6R[(15.32±2.62)ng/L]and IL-22[(63.61±6.95)ng/L]in the severe group were obviously increased at admission(P<0.05),by drawing the receiver operating characteristic,it was found that the AUC of IL-6R,IL-22 and their combined diagnosis of severe ulcerative colitis was 0.85,0.85 and 0.92,respectively,and their combined diagnosis was obviously better than that of IL-6R and IL-22 alone(Z=3.58,3.42;P=0.003,0.006);by analyzing the general clinical data of the patients,it was found that the prognosis of patients with ulcerative colitis was related to whether they had extraintestinal manifestations,C-reactive protein(CRP),pro-cal-citonin(PCT),erythrocytesedimentrate(ESR),faecal calreticulin(FC),faecal lactoferrin(FL),IL-6R and IL-22 levels(P<0.05),but not to gender and age(P>0.05),multiple Logistic regression analysis showed that CRP,PCT,ESR,FC,FL,IL-6R and IL-22 were all risk factors affecting the prognosis of ulcerative colitis patients(P<0.05).Receiver operating characteristic found that the AUC of pa-tients with ulcerative colitis predicted by IL-6R,IL-22 and their combination was 0.81,0.83 and 0.90,respectively,and their combined predicted was obviously better than that predicted by IL-6R and IL-22 alone(Z=3.70,3.18;P<0.001,P=0.002).Conclusion The serum levels of IL-6R and IL-22 in patients with ulcerative colitis increase with the severity of the patient's disease,both are both risk factors affecting the prognosis of patients with ulcerative colitis,and they have an auxiliary diagnostic value in the prediction of the severity of the patient's disease and clinical outcome.
Colitis,ulcerativeInterleukin-6 receptorInterleukin-22Severity of the conditionClinical outcomes
万方数据
维普
