Arteriosclerosis in patients with hypertension complicated with OSAHS and its correlation analysis
Objective To investigate the effects of hypertension and obstructive sleep apnea hypopnea syndrome(OSAHS)on pa-tients' arteriosclerosis and to analyze the correlation between arteriosclerosis and hypertension grade,parameters related to sleep breathing,and risk factors for cardiovascular disease.Methods Patients admitted to the Department of Cardiology and Jiangbei Hospi-tal of Zhongda Hospital Affiliated to Southeast University from October 2020 to December 2021 for sleep breathing monitoring were se-lected.According to the diagnosis,the patients were assigned into 24 cases without hypertension and OSAHS(control group),35 cases without hypertension and OSAHS(single OSAHS group),53 cases with hypertension and OSAHS(single HBP group),and 92 cases with hypertension and OSAHS(double positive group).The difference in brachial and ankle pulse wave velocity(baPWV)among the four groups was compared.At the same time,baPWV>1 800 cm/s was used as the boundary to determine whether baPWV was abnor-mal or not.Multivariate unconditional logistic regression analysis was performed as the dependent variable.Results baPWV(1 952.70±466.75)cm/s of hypertension combined with OSAHS(double positive group)was significantly higher than that of hypertension alone(1 664.96±306.52)cm/s,OSAHS alone(1 710.29±440.61)cm/s and control group(1 379.63±209.46)cm/s.baPWV of pure hy-pertension group and OSAHS group was higher than that of control group.There was no significant difference in baPWV between sim-ple hypertension group and simple OSAHS group(P>0.05).Multivariate logistic regression with baPWV abnormality as dependent variable showed that age,apnea hypopnea index(AHI)grade,blood pressure grade and HBA1c were risk factors for increased baPWV.There was no significant correlation with years of hypertension,gender,minimum oxygen saturation and so on.Conclusions Hyper-tension and OSAHS are significantly related to the changes of early atherosclerosis indicators.Meanwhile,the higher the AHI and blood pressure level,the more obvious the abnormalities of early atherosclerosis indicators.Early detection and control of hypertension can delay the changes of atherosclerosis indicators.Due to the existence of OSAHS,the degree of arteriosclerosis in hypertensive popu-lation is obviously abnormal.Early screening and intervention of OSAHS in hypertensive population may effectively slow down the de-velopment of arteriosclerosis.
万方数据
维普
