The early predictive value of NLR and PLR for the severity and prognosis of severe acute pancreatitis
Objective To explore the early predictive significance of the neutrophil to lymphocyte ratio(NLR)and platelet to lympho-cyte ratio(PLR)for assessing the severity and prognosis of severe acute pancreatitis(SAP).Methods A retrospective analysis was con-ducted on clinical data from 290 patients receiving initial treatment for acute pancreatitis at the First People's Hospital of Zunyi City from January 2018 and March 2023.The patients were categorized into the SAP group(n=105)and the non-SAP group(n=185).The clin-ical data and biochemical markers between the two groups were compared.The ROC curve was used to analyze the predictive perfor-mance of NLR and PLR for SAP.Then SAP patients were assigned into NLR and PLR elevated group(n=45)and non-elevated group(n=60),and the clinical and prognostic data were compared.Results The baseline data was comparable.Acute physiology and chronic health evaluation Ⅱ(APACHEⅡ)and Ranson were higher in SAP patients[6(5,8)points vs.17(14,20)points,1(1,2)points vs.4(3,4)points,P<0.001].NLR and PLR were significantly higher in the SAP group(P<0.05).ROC curve analysis results showed that the cut-off value was 6.58 and 157.89,respectively.In SAP patients,NLR and PLR elevated group had disadvantages in hospital stay(P=0.003),abrosia time(P<0.001),drainage tube(P<0.001),hospitalization expenses(P=0.002)and mortality rate(P=0.047).Conclu-sions The increase of NLR and PLR is valuable in the early diagnosis and prognosis of SAP,and the rapid progression to SAP in non-SAP patients should be warned.Elevated NLR and PLR indicate critical illness,poor outcome and prognosis of SAP patients.
Pancreatitis,acute necrotizingNeutrophil to lymphocyte ratioPlatelet to lymphocyte ratioForecastPrognosis
万方数据
维普
