Changes of neurotrophic factor and thyroid hormone levels in elderly depressed patients with insomnia symptoms
Objective To investigate the changes in the levels of brain-derived neurotrophic factor(BDNF),glial cell line-derived neurotrophic factor(GDNF),and thyroid hormone(TH)in elderly patients with comorbid insomnia symptoms and depression.Methods The clinical data of 124 patients with depression admitted to The Sixth Clinical Medical College of Hebei University from July 2016 to March 2018 were retrospectively analyzed.The patients were divided into two groups:a group with comorbid insomnia symptoms(n=65)and a group without insomnia symptoms(n=59).The differences in serum BDNF,GDNF,and TH levels were compared between the two groups,and the factors influencing insomnia in elderly depression were analyzed.Results The levels of BDNF in patients with in-somnia were significantly lower than those without insomnia[981.09(924.37,1 031.63)ng/L,1 062.64(1 012.79,1 137.61)ng/L,P<0.05].The levels of GDNF in patients with insomnia were significantly lower than those without insomnia[0.41(0.31,0.50)ng/L,0.56(0.44,0.69)ng/L,P<0.05,P<0.05].Compared with the insomnia group,the expression levels of triiodothyronine(T3),thyroxine(T4),free triiodothyronine(FT3),free Thyroid hormone(FT4)and thyroid-stimulating hormone(TSH)in patients with insomnia,there was no statistical significance(P>0.05).In addition,there was a strong correlation between the levels of BDNF and GDNF(P<0.05).Multiple Logistic regression analysis showed that serum BDNF and GDNF were protective factors of insomnia(BDNF:OR=0.991;GDNF:OR=0.008).Conclusion Elevating serum BDNF and GDNF levels to normal ranges can potentially serve as a promising avenue for im-proving insomnia in elderly patients with depression.
DepressionSleep initiation and maintenance disordersBrain-derived neurotrophic factorGlial-derived neurotroph-ic factorThyroid hormoneAged
万方数据
维普
