Objective To analyze the relationship between soluble angiotensin converting enzyme 2(sACE2)level and myocardial in-jury in children with Mycoplasma pneumoniae pneumonia(MPP).Methods A total of 108 children with MPP admitted to 81st Group Military Hospital from February 2021 to November 2022 were collected.According to the severity of the condition,they were grouped into a severe MPP group of 30 cases and a mild MPP group of 78 cases.Fifty healthy children who underwent physical examination dur-ing the same period were collected as the control group;children with MPP were grouped into an occurrence group of 23 cases and an non occurrence group of 85 cases based on whether they experienced myocardial injury.Enzyme-linked immunosorbent assay was ap-plied to measure serum sACE2 level;clinical medical record data and biochemical indicators of MPP children were collected,and com-pared between groups;Pearson method was applied to analyze the correlation between sACE2 and biochemical indicators;Logistic re-gression was applied to analyze the influencing factors of myocardial injury in children with MPP;ROC curve was applied to analyze the predictive value of sACE2 level for myocardial injury in children with MPP.Results The serum level of sACE2 in children with se-vere MPP group,mild MPP group,and control group[(56.19±6.13)U/L,(42.36±6.02)U/L,(28.15±5.97)U/L]decreased sequentially,the serum level of sACE2 in children with MPP in the occurrence group were higher than those in the non occurrence group(P<0.05);the differences in fever severity,MP antibody titer,duration of fever,duration of macrolide medication use,cough properties,other extrapul-monary complications,chest X-ray manifestations,electrocardiogram abnormalities,C-reactive protein(CRP),lactate dehydrogenase(LDH),creatine kinase(CK-MB),phosphocreatine kinase(CK),red blood cell distribution width(RDW),cardiac troponin(cTnI),N-terminal pro-B-type natriureticpeptide(NT-proBNP)and platelet count(PLT)were statistically obvious(P<0.05);the level of sACE2 was positively correlated with LDH,NT proBNP,cTnI,CK,RDW,CRP,and negatively correlated with PLT(P<0.05);SACE2 and CK-MB were influencing factors for myocardial injury in MPP children(P<0.05);the AUC of myocardial injury in MPP patients evaluated by sACE2 level was 0.94[95%CI:(0.88,0.98)],with sensitivity and specificity of 86.96%and 85.88%,respectively.Conclusions The level of sACE2 is closely related to myocardial injury in children with MPP,and is a influencing factor for the occurrence of myocardial injury in children with MPP.It has certain predictive value for the occurrence of myocardial injury.
Pneumonia,mycoplasmaSoluble angiotensin converting enzyme 2Myocardial damageInfluencing factorsPre-dictive value
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