A preliminary study on the relationship between soluble ACE2 level and myocardial injury in children with mycoplasma pneumonia
Objective To analyze the relationship between soluble angiotensin converting enzyme 2(sACE2)level and myocardial in-jury in children with Mycoplasma pneumoniae pneumonia(MPP).Methods A total of 108 children with MPP admitted to 81st Group Military Hospital from February 2021 to November 2022 were collected.According to the severity of the condition,they were grouped into a severe MPP group of 30 cases and a mild MPP group of 78 cases.Fifty healthy children who underwent physical examination dur-ing the same period were collected as the control group;children with MPP were grouped into an occurrence group of 23 cases and an non occurrence group of 85 cases based on whether they experienced myocardial injury.Enzyme-linked immunosorbent assay was ap-plied to measure serum sACE2 level;clinical medical record data and biochemical indicators of MPP children were collected,and com-pared between groups;Pearson method was applied to analyze the correlation between sACE2 and biochemical indicators;Logistic re-gression was applied to analyze the influencing factors of myocardial injury in children with MPP;ROC curve was applied to analyze the predictive value of sACE2 level for myocardial injury in children with MPP.Results The serum level of sACE2 in children with se-vere MPP group,mild MPP group,and control group[(56.19±6.13)U/L,(42.36±6.02)U/L,(28.15±5.97)U/L]decreased sequentially,the serum level of sACE2 in children with MPP in the occurrence group were higher than those in the non occurrence group(P<0.05);the differences in fever severity,MP antibody titer,duration of fever,duration of macrolide medication use,cough properties,other extrapul-monary complications,chest X-ray manifestations,electrocardiogram abnormalities,C-reactive protein(CRP),lactate dehydrogenase(LDH),creatine kinase(CK-MB),phosphocreatine kinase(CK),red blood cell distribution width(RDW),cardiac troponin(cTnI),N-terminal pro-B-type natriureticpeptide(NT-proBNP)and platelet count(PLT)were statistically obvious(P<0.05);the level of sACE2 was positively correlated with LDH,NT proBNP,cTnI,CK,RDW,CRP,and negatively correlated with PLT(P<0.05);SACE2 and CK-MB were influencing factors for myocardial injury in MPP children(P<0.05);the AUC of myocardial injury in MPP patients evaluated by sACE2 level was 0.94[95%CI:(0.88,0.98)],with sensitivity and specificity of 86.96%and 85.88%,respectively.Conclusions The level of sACE2 is closely related to myocardial injury in children with MPP,and is a influencing factor for the occurrence of myocardial injury in children with MPP.It has certain predictive value for the occurrence of myocardial injury.
Pneumonia,mycoplasmaSoluble angiotensin converting enzyme 2Myocardial damageInfluencing factorsPre-dictive value
万方数据
维普
