Resting-state functional magnetic resonance imaging study in patients with Wilson disease with mild cognitive impairment
Objective To explore the effects of resting state functional MRI(rs-fMRI)and neuropsychological methods on Wilson dis-ease(WD)and the value of studying brain network and function differences in patients with mild cognitive impairment(MCI).Methods From March 2023 to November 2023,the First Affiliated Hospital of Anhui University of Chinese Medicine recruited patients meeting the diagnostic criteria for WD compiled by the Genetic Metabolic Liver Disease Collaboration Group of the Hepatology Branch of the Chinese Medical Association.The patients were divided into WD-MCI group and WD group without mild cognitive impairment(WD-nMCI)group according to the scores of the Montreal Cognitive Assessment Scale(MoCA),the Minimum Mental State Examination Scale(MMSE)and the activity of daily living(ADL)scale.The resting FMRI images and the complete set of cognitive function assessment scale data of all subjects were collected.DPARSF software was used to preprocess the magnetic resonance data and construct the differ-ential brain region,and MATLAB software platform was used to correct the amplitude of low frequency fluctuation(ALFF)and function-al connectivity(FC)values through the steps of second-order analysis,parameter estimation and result comparison.Then the differen-tial brain region and scale score were statistically analyzed.Results In comparison to the WD-nMCI group,the scale scores of the WD-MCI group in the areas of numerical breadth,prospective and retrograde memory,attention,frontal lobe functioning were 13.0(12.0,13.5)score,19.0(13.0,20.5)score,14.0(13.0,16.0)score,18.0(16.0,19.0)score,and in the WD-nMCI group 14.0(14.0,15.0)score,31.0(30.8,32.0)score,17.5(17.0,18.0)score,19.0(19.0,20.0)score.The difference was statistically significant(P<0.05).The ALFF value of the left parahippocampal gyrus increased in WD-MCI group.ALFF decreased in the left supplementary motor area,the right supplementary motor area and the left anterior central gyrus.When the seed point was set as bilateral parahippocampal gyrus,the func-tional connection values of left lingual gyrus,right lingual gyrus and left pericalar cleft cortex,right superior temporal gyrus and right transverse temporal gyrus decreased in WD-MCI group.Conclusions This study reveals that the difference in cognitive domain dam-age between WD-MCI patients and WD-nMCI patients is related to the brain region with the change of ALFF value.According to the re-sults of the connection strength of brain network,it can be suggested that the cognitive impairment of WD-MCI patients may be related to the reduced tightness between the default mode network and the visual and auditory network.
Hepatolenticular DegenerationMild cognitive impairmentFunctional magnetic resonanceAmplitude of low fre-quency fluctuationFunctional connectivity
万方数据
维普
