A case of JAK2,CALR,MPL co-expression ET and review of the literature
Objective To investigate the clinical and laboratory features of a patient with CALR,JAK2 and MPL driver mutations positive Essential thrombocytosis ET,it is suggested that clinicians should detect the mutations of related driver genes more accurately during the diagnosis of the disease..Methods On February 17,2022,bone marrow fluid from patients with primary thrombocytosis at Linyi Central Hospital was collected and sent for testing at Ji'nan Jinyu Medical Testing Center.Next-generation sequencing was used to detect JAK2,CALR and MPL gene mutations in this patient with ET and to analyze the clinical and laboratory characteristics of pa-tients with all three driver gene mutations of JAK2,CALR and MPL expressed in conjunction with the literature.Results Patients were detected positive for three driver mutations in JAK2,CALR and MPL and showed increased platelets and normal red blood cell count and hemoglobin.Conclusion In order to improve the understanding of ET or even myeloproliferative neoplasms(MPN),more accurate next-generation sequencing for their gene mutations is needed in the diagnostic process as much as possible.
万方数据
维普
