Correlation between serum Slit2 protein level and coronary artery lesions in elderly patients with coronary heart disease
Objective To detect the expression level of Slit2 protein in the serum of elderly patients with coronary heart disease,and to analyze its correlation with the severity of the disease.Methods A total of 127 elderly patients with coronary heart disease admitted to 3201 Hospital from January 2020 to January 2022 were gathered as the research group,another 80 healthy people who underwent physical examination in our hospital were gathered as the control group.According to degree of coronary stenosis(Gensini)classifica-tion,the study group was divided into mild lesion group(52 cases),moderate lesion group(43 cases)and severe lesion group(32 cases).General clinical data of patients were collected and serum Slit2 protein levels were detected.Spearman rank correlation was used to an-alyze the correlation between serum Slit2 protein and the severity of coronary heart disease patients;Logistic regression analysis was used to analyze the influencing factors of severe coronary lesions in elderly patients with coronary heart disease;receiver operating char-acteristic curve(ROC curve)was used to analyze the predictive power of serum Slit2 protein expression level for severe coronary lesions in coronary heart disease.Results The levels of total cholesterol(TC),triglyceride(TG)and low-density lipoprotein cholesterol(LDL-C)in the mild lesion group,moderate lesion group and severe lesion group were significantly higher than those in the control group,and the level of LDL-C increased with the severity of the lesion(P<0.05).The serum Slit2 protein expression level of the study group[(1.94±0.45)µg/L]was significantly lower than that of the control group[(3.52±0.80)µg/L](P<0.05).The serum Slit2 protein expression level of patients with mild[(2.47±0.55)µg/L],moderate[(1.85±0.41)µg/L]and severe disease group[(1.20±0.34)µg/L]was decreased succes-sively(P<0.05).The Spearman analysis showed that the expression level of Slit2 protein in serum of patients with coronary heart dis-ease was negatively correlated with the severity of the disease(rs=-0.53,P<0.05).Multivariate Logistic regression analysis showed that serum Slit2 protein and LDL-C were the influencing factors of severe coronary lesions in elderly patients with coronary heart disease(P<0.05).The area under ROC curve(AUC)of serum Slit2 was 0.93,the sensitivity was 93.75%,the specificity was 88.37%,the trunca-tion value was 1.54 µg/L,and the Joaden index was 0.82.The AUC of serum LDL-C was 0.89,the sensitivity was 87.50%,the specifici-ty was 86.05%,the truncation value was 3.48 mmol/L,and the Joaden index was 0.74.The AUC of the two combined was 0.96,the sen-sitivity was 96.87%,the specificity was 88.37%,and the Joaden index was 0.85.Slit2 alone predicted a slightly higher AUC than LDL-C alone for severe coronary lesions(P>0.05),but the combination of the two predicted a higher AUC than LDL-C for severe coronary le-sions(Z=2.10,P=0.036),and was more sensitive.Conclusions The expression level of serum Slit2 protein is significantly decreased in elderly patients with coronary heart disease,and is correlated with the severity of coronary artery disease.Slit2 protein can predict the severity of coronary artery disease in elderly patients with coronary heart disease,and has high clinical application value.
万方数据
维普
