Study on the relationship between the expression of serum free fatty acid and heart type fatty acid binding protein and atherosclerotic plaque in type 2 diabetes patients
Objective To investigate the relationship between the expression of serum free fatty acid(FFA)and heart type fatty acid binding protein(H-FABP)and atherosclerotic plaque(CAP)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 302 patients with T2DM admitted to the fourth Central Hospital of Baoding from June 2020 to June 2022 were selected as the research ob-jects.The subjects were further grouped into CAP group(165 cases)and non-CAP group(137 cases)by carotid ultrasound examination.The levels of serum FFA and H-FABP were detected by enzyme-linked immunosorbent assay(ELISA);Logistic multiple factor regres-sion was applied to analyze the influencing factors of CAP;the levels of serum FFA,H-FABP and their correlation with clinical data were analyzed by Spearman method;Receiver operating characteristic curve(ROC curve)was used to evaluate the diagnostic efficacy of serum FFA,H-FABP and their combination for CAP.Results Compared with non-CAP group,the age,history of hypertension,C-reac-tive protein(CRP),triacylglycerol(TG),low-density lipoprotein cholesterol(LDL),apolipoprotein A(ApoA),FFA,H-FABP[(4.63±1.43)µg/Lvs.(3.68±1.05)µg/L]levels in CAP group increased obviously(P<0.05),the level of LPA decreased obviously(P<0.05).Logistic analysis showed that age,CRP,TG,LDL,FFA and H-FABP were independent risk factors for CAP in T2DM patients(P<0.05).The se-rum FFA of T2DM patients with CAP was positively correlated with the levels of H-FABP,age,CRP,TG and LDL(rs=0.61,0.59,0.52,0.57,0.55,P<0.05).Serum H-FABP was positively correlated with age,CRP,TG and LDL levels(rs=0.58,0.53,0.57,0.54,P<0.05).The ROC curve results showed that the AUC of FFA,H-FABP levels in serum and their combination in predicting CAP in T2DM pa-tients were 0.71,0.74 and 0.84,respectively,and the AUC of combined prediction was obviously higher than that of the two alone(Z=3.65,2.68,P<0.05).Conclusion The levels of FFA and H-FABP increase in the serum of T2DM patients with CAP,which are closely related to age,CRP,TG and LDL,and are expected to become diagnostic factors for the occurrence of CAP in T2DM patients.
Diabetes mellitus,type 2Plaque,atheroscleroticFree fatty acidHeart type fatty acid binding proteinCorrela-tionDiagnosis
万方数据
维普
