Clinical study of Bushen Tiaozhou prescription on repeated implantation failure of IVF-ET with chronic endometritis
Objective To observe the effects of Bushen Tiaozhou prescription on endometrial receptivity,embryo implantation rate,uterine immune microenvironment and pregnancy outcome in patients with repeated implantation failure in vitro fertilization-embryo transfer(IVF-ET)complicated with chronic endometrial inflammation.Methods A total of 150 IVF-ET cases with repeated embryo implantation failure and chronic endometrial inflammation were selected from Reproductive Medicine Center of Sanmenxia Hospital of the Yellow River from February 2018 to February 2021,and were divided by random number table method.The 75 patients in the symptomatic group received anti-infection treatment in the first menstrual cycle after IVF-ET failure,stopped taking the drug during menstrual period,and continued taking the drug after purification for a total of 14 days,and 75 patients in the Bushen Tiaozhou pre-scription group were treated with Bushen Tiaozhou prescription for 30 consecutive days.The activity levels of tumor necrosis factor-α(TNF-α),glutathione peroxidase(GSH-Px),interleukin4(IL-4),superoxide dismutase(SOD),interleukin-1β(IL-1β),anti-superoxide anion radical(anti-O2-)and the positive rate of CD138 in the two groups were detected before and after treatment.CD56+expression was detected,endometrial thickness,uterine artery blood flow index,pulse index and resistance index were detected,Salle and TCM syndrome scores were given to patients before and after treatment,and clinical pregnancy rate,number of transplanted embryos,early abortion rate,embryo implantation rate and live birth rate were recorded in the treatment group and Bushen Tiaozhou prescription group.Results The contents of TNF-α,IL-1β,CD56+and the positive rate of CD138 in Bushen Tiaozhou prescription were lower than those of the Symptomatic group(P<0.05);the content of IL-4 in Bushen Tiaozhou prescription was higher than Symptomatic group(P<0.05).The contents of SOD,anti-O2-activity and GSH-Px in Bushen Tiaozhou prescription were higher than those of the Symptomatic group(P<0.05).The endometrial thickness and blood flow index of uterine artery in Bushen Tiaozhou prescription were higher than those of the Symptomatic group(P<0.05);the uterine artery pulsation index and resistance index in Bushen Tiaozhou prescription were lower than those of the Symptomatic group(P<0.05).The TCM syndrome score of Bushen Tiaozhou prescription was lower than that of the Symptomatic group(P<0.05);the Salle score of Bushen Tiaozhou prescription was higher than that of the Symptomatic group(P<0.05).The embryo implantation rate,clinical pregnancy rate and live birth rate in Bushen Tiaozhou prescription were higher than those of the Symptomatic group(33.33%,42.67%,41.33%)vs.(22.36%,26.67%,22.67%),and the difference was statistically significant(P<0.05),while there was no statistically significant difference in early abortion rate between the two groups(P>0.05).Conclusions In the treatment of patients with repeated embryo implantation failure of IVF-ET and chronic endometrial inflammation,Bushen Tiaozhou pre-scription can inhibit body inflammation,regulate uterine immune microenvironment,reduce oxidative stress damage,improve endome-trial receptivity,alleviate clinical symptoms and improve pregnancy outcomes..
万方数据
维普
