Objective To investigate the rules and characteristics of adverse drug reactions(ADR)of Reduning injection,so as to pro-vide evidence for clinical rational drug use.Methods Three hundred and twenty-five cases of ADR related to Reduening injection which were collected from January 2012 to December 2022 based on database of Center for ADR Monitoring of Wuhan city were ana-lyzed statistically.Results In 325 cases of Reduning injection ADR,the majority of ADR occurred in children under 6 years old,most of which were combined medication(52.62%).The influencing factors of irrational drug use leading to ADR were unreasonable dose(14.77%),off-label drug use(1.54%)and unreasonable solvent(1.54%).ADR mainly occurred within 30 min of medication,and the main systematic-organ and clinical manifestations were skin and accessory damage(52.71%),followed by systemic damage(21.26%).Conclusion In clinical practice,it is necessary to strengthen ADR risk management of Reduning injection in children(especially un-der 6 years old),and avoid unreasonable use of excessive dosage,off-label and combined drug use with insufficient evidence of evi-dence-based medicine,so as to avoid increasing the risk of ADR and ensure the safe and effective use of Reduning injection.
关键词
药物相关性副作用和不良反应/抗病毒药/中草药/热毒宁注射液/安全用药/分析
Key words
Drug-related side effects and adverse reactions/Antiviral agents/Drugs,Chinese herbal/Reduning injection/Safe medication/Analysis
维普
万方数据