Analysis of a case of transient erythema caused by amifostine in a breast cancer patient
Objective To analyze the occurrence characteristics,risk factors,and management of adverse reaction of transient erythe-ma caused by injectable amifostine,and to provide references for clinical safe medication.Methods A case of transient erythema caused by amifostine was reported in Jixi Ji Mine Hospital from March 28 and April 13,2023 respectively,and literature of skin adverse reactions caused by amifostine published at home and abroad,and the clinical characteristics,management measures and prognosis of adverse reactions were extracted and summarized.Results Skin reactions caused by amifostine were rare,only five literatures about skin adverse reactions caused by amifostine were collected,all of which were foreign cases.The transient erythema in this patient was not completely similar to the description of erythema in the literatures.Combined with the comprehensive analysis of literature retrieval,the skin adverse reaction in this case did not exclude allergy to the components of amifostine,allergy to the related excipients in amifos-tine for injection,or related to a cytotoxic T-cell mediated pathogenesis.Conclusions When using amifostine in clinical,it is necessary to ask the patient whether he has allergic history of amifostine or mannitol and other related drugs,and whether he has a history of auto-immune diseases.It is recommended to conduct a skin assessment before each administration of amifostine,and pay attention to the re-lated indicators of C-reactive protein to make relevant drug reference.If skin related reactions occur,the medication should be discontin-ued immediately,topical and systemic medications can be used to improve symptoms to ensure medication safety.
AmifostineTransient changeRed spotAdverse drug reactionRelevancyPrevention and treatment
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维普
