Progress in the treatment of chronic sinusitis with bacterial lysate
Chronic sinusitis(CRS)is a common otorhinolaryngological disease.Due to the high prevalence and recurrence rate of CRS,it brings huge health and economic burden to individuals,families and the whole society.At present,the prevalence of CRS is still on the rise.Although great progress has been made in the treatment and control of CRS in the past few decades,there are still some limita-tions.Therefore,it is particularly important to find other prevention strategies.In recent years,some scholars have proposed that non-specific immunomodulators can change the response of the immune system to infectious diseases.We have collected data on the effec-tiveness of nonspecific immunomodulators in the treatment of CRS.The data reveal that the effect of oral immunomodulators on CRS is mainly achieved through the intestinal-pulmonary immune axis and increasing the NO response of paranasal sinus epithelial cells and the frequency of cilia wobble.These drugs may provide another new method for relieving nasal symptoms and preventing CRS infection and recurrence.At present,the most widely used non-specific immunomodulator is bacterial lysate.This paper summarizes the action mechanism of bacterial lysate in CRS and related clinical research progress,in order to provide some theoretical guidance for the appli-cation of bacterial lysate in CRS.
万方数据
维普
