Progress and clinical significance of cross-reaction between pollen and fruit
Pollen,as a common inhalant sensitizer,cross-reacts with common allergen proteins in fruits.Molecular epitopes in higher order structures of fruit allergen proteins are immunogenic and these molecular epitope domains interact with specific IgE causing aller-gic reactions of varying severity.Pollen and fruit cross-allergic reactions cause complex clinical manifestations,and their diagnosis,treatment and management problems need to be solved urgently.Allergens causing cross-reactivity are diagnosed by epitope identifica-tion of pollen and fruit allergens to prevent and treat allergic diseases.This article reviews the phenotypic characteristics,plant distribu-tion characteristics,regionality,clinical symptoms and component diagnosis of fruit panallergens and pollen allergens,focusing on the related characteristics of rosaceae fruit panallergens and a variety of plant pollen sensitizing proteins,as well as the characteristics of Artemisia pollen and fruit cross-allergy in China.The identification of allergens is the direction of accurate diagnosis and treatment of allergic diseases and has guiding significance for clinical work.
万方数据
维普
