Predictive analysis of combined detection of neutrophil to lymphocyte ratio and carcinoembryonic antigen expression in peripheral blood for the effect of concurrent radiotherapy and chemotherapy in locally advanced cervical cancer
Predictive analysis of combined detection of neutrophil to lymphocyte ratio and carcinoembryonic antigen expression in peripheral blood for the effect of concurrent radiotherapy and chemotherapy in locally advanced cervical cancer
Objective To explore the predictive value of combined detection of neutrophil to lymphocyte ratio(NLR)and carcinoem-bryonic antigen(CEA)expression in peripheral blood for the effect of concurrent radiotherapy and chemotherapy in locally advanced cervical cancer(LACC).Methods A total of 120 LACC patients who visited Baoding First Central Hospital from January to December 2021 were regarded as the study subjects.The 120 LACC patients were grouped into effective group[complete response(CR)/partial re-sponse(PR),n=94]and ineffective group[stable disease(SD)/progressive disease(PD),n=26]according to the effect of concurrent radio-therapy and chemotherapy,the expression levels of NLR,CEA and squamous cell carcinoma associated antigen(SCC-Ag)in peripheral blood of the two groups were compared before treatment.Multivariate logistic regression analysis was applied to analyze the factors af-fecting the effect of concurrent radiotherapy and chemotherapy in LACC patients;the predictive value of the expression levels of NLR and CEA in peripheral blood for the effect of concurrent radiotherapy and chemotherapy in LACC patients was analyzed by the ROC curve.Results Compared with group B,the expression levels of NLR(2.51±0.24 vs.2.97±0.36),CEA[(6.84±0.92)μg/L vs.(8.77±1.03)μg/L]and SCC-Ag[(5.98±1.19)μg/L vs.(9.06±1.65)μg/L]in group A were significantly lower(P<0.05).Logistic regression anal-ysis showed that high expression of NLR,CEA,SCC-Ag,positive lymph nodes,non-squamous cell carcinoma and high FIGO stage were independent risk factors affecting the effect of concurrent chemoraotherapy in LACC patients(P<0.05).The ROC results showed that the AUC of NLR alone predicting the effect of concurrent radiotherapy and chemotherapy in LACC patients was 0.81,95%CI:(0.73,0.87),its sensitivity and specificity were 69.23%and 86.17%,respectively,and the best cut-off value was 2.96;the AUC of CEA alone predicting the effect of concurrent radiotherapy and chemotherapy in LACC patients was 0.86,95%CI:(0.79,0.92),its sensitivity and specificity were 73.08%and 85.11%,respectively,and the best cut-off value was 8.06 μg/L;The AUC of SCC-Ag level alone in predict-ing the effect of concurrent chemoradiotherapy in LACC patients was 0.88,95%CI:(0.80,0.95),the sensitivity and specificity were 69.23%and 85.11%,respectively,and the optimal cut-off value was 8.28 μg/L;The AUC(0.94)predicted by the combination of the three methods was significantly greater than that predicted by NLR alone(Z=2.61,P=0.009),CEA alone(Z=2.57,P=0.010)and SCC-Ag alone(Z=1.99,P=0.046).Conclusion The levels of NLR and CEA in LACC patients with effective synchronous radiochemothera-py are low,the combined detection of the two has a high predictive value for the effect of LACC concurrent radiotherapy and chemother-apy.
关键词
宫颈肿瘤/同步放化疗/中性粒细胞与淋巴细胞比值/癌胚抗原/预测价值
Key words
Uterine cervical neoplasms/Synchronous radiochemotherapy/Neutrophil to lymphocyte ratio/Carcinoembryonic an-tigen/Predictive value
维普
万方数据