Objective To explore the occurrence of tinnitus and its correlation with inflammation response in patients with otitis me-dia with effusion(OME).Methods A total of 104 patients with OME admitted to the Chaohu Hospital of Anhui Medical University were enrolled as the research objects between January 2021 and August 2022,while 104 healthy controls during the same period were enrolled as control group.The inflammatory response indexes and occurrence of tinnitus in the two groups were compared.According to presence or absence of tinnitus,OME patients were divided into tinnitus group(n=19)and non-tinnitus group(n=85),and inflammatory response indexes in the two groups were compared.The diagnostic value of inflammatory response indexes for tinnitus was analyzed.Re-sults The levels of IL-6,IL-8 and TNF-α in OME group were higher than those in control group(P<0.05).The incidence of tinnitus in OME group was higher than that in control group(18.27%vs.4.81%,P<0.05).The levels of IL-6,IL-8 and TNF-α in tinnitus group were higher than those in non-tinnitus group(P<0.05).ROC curves analysis showed that AUC and cut-off values of IL-6,IL-8 and TNF-α in the diagnosis of tinnitus were(0.77,4.04 ng/L),(0.81,12.41 ng/L)and(0.69,3.96 ng/L),respectively.AUC of combined detection was 0.89,which was greater than that of single index(P<0.05).Conclusion Tinnitus is severe in OME patients.IL-6,IL-8 and TNF-α can be applied to diagnose tinnitus,and diagnostic value of combined detection is higher.
关键词
伴渗出液中耳炎/耳鸣/白细胞介素-6/白细胞介素-8/肿瘤坏死因子-α
Key words
Otitis media with effusion/Tinnitus/Interleukin-6/Interleukin-8/Tumor necrosis factor-α
维普
万方数据