Correlation analysis of patients with breast cancer and thyroid cancer
Objective To analyze the clinical and pathologyical characteristics of primary breast cancer and thyroid cancer and ex-plore potential correlations between the two primary tumors.Methods A retrospective analysis was conducted on 92 female patients with simultaneous breast cancer and thyroid cancer(bilateral primary cancer group)admitted to the People's Hospital of Zhongshan from January 2008 to July 2023.Additionally,100 cases of single breast cancer(breast cancer group)and 100 cases of single thyroid cancer(thyroid cancer group)treated in the past two years were collected.The study analyzed the general characteristics of the bilateral primary cancer group,the sequence of tumor onset,and compared the general characteristics,pathological features,lymph node metas-tasis,estrogen receptor(ER),progesterone receptor(PR),and HER-2 expression,as well as molecular subtypes between the bilateral primary cancer group and the breast cancer group.It also compared the general characteristics,pathological features,lymph node me-tastasis,thyroid hormone,and antibody levels between the bilateral primary cancer group and the thyroid cancer group.Results In the bilateral primary cancer group,86 cases had breast cancer diagnosed first,while 6 cases had thyroid cancer diagnosed first,indicat-ing that the majority of patients(>90%)developed breast cancer before thyroid cancer.Compared to the breast cancer group,the bilater-al primary cancer group had a younger age at diagnosis,more were premenopausal,had larger tumor sizes,and showed more positive ex-pression of ER and PR,with statistically significant differences(all P<0.05).Compared to the thyroid cancer group,the bilateral prima-ry cancer group had an increased likelihood of tumors occurring on both sides and significantly elevated levels of triiodothyronine(T3)and thyroxine(T4)levels(all P<0.05).Conclusions There is a correlation between breast cancer and thyroid cancer.Clinically,breast cancer patients who are ER-positive,PR-positive,younger,premenopausal,and have larger tumor sizes should pay attention to routine thyroid examinations.Similarly,thyroid cancer patients with high levels of T3 and T4 should not overlook the possibility of ma-lignancy in the breast.
万方数据
维普
