The predictive value of serum ZAG combined with HMGB1 for short-term recurrence risk in epilepsy patients
Objective To explore the predictive value of serum zinc α2 glycoprotein(ZAG)combined with high mobility group pro-tein B1(HMGB1)for short-term recurrence risk in epilepsy patients.Methods A total of 110 epileptic patients who experienced short-term(1 week)recurrence after treatment in the Xiehe Hospital of Tangshan from February 2022 to February 2023 were collected as the study group,another 110 patients with generalized seizures who did not recur within a short period of time(1 week)after treatment in the Affiliated Hospital of Tangshan Vocational and Technical College during the same period were selected as the control group.Pear-son method was applied to analyze the correlation between the expression levels of serum ZAG and HMGB1 in patients with short-term recurrent epilepsy,logistic regression to analyze the relevant factors affecting short-term recurrence in epilepsy patients,and receiver operating characteristic(ROC)curve to analyze the predictive value of serum ZAG and HMGB1 for short-term recurrence of epilepsy patients.Results The expression level of serum ZAG[(38.11±4.21)mg/L vs.(41.76±5.36)mg/L]in the study group was lower than that in the control group,while the expression level of serum HMGB1[(6.07±1.63)μg/L vs.(4.89±0.92)μg/L]was higher than that in the control group(P<0.05).The expression levels of serum ZAG and HMGB1 in patients with short-term recurrent epilepsy showed an obvi-ous negative correlation(r=-0.80,P<0.05).The proportions of patients with seizure frequency≥1 time/month before treatment and pa-tients receiving multi-drug combination therapy in the study group were higher than those in the control group(P<0.05).Seizure fre-quency≥1 time/month before treatment,multi-drug combination therapy,and HMGB1 were risk factors for short-term recurrence in ep-ilepsy patients,while ZAG was a protective factor(P<0.05).The areas under the curve(AUC)of serum ZAG and HMGB1 for predicting short-term recurrence in epilepsy patients were[0.73,95%CI:(0.68,0.77)and 0.73,95%CI:(0.69,0.77)],respectively,and the AUC of the combined detection of the two was 0.79,95%CI:(0.75,0.83),which was superior to that of the individual detection of serum ZAG and HMGB1(Zcombination-ZAG=3.10,Zcombination-HMGB1=2.75,P=0.002,0.005).Conclusion The expression levels of serum ZAG and HMGB1 are closely related to short-term recurrence in epilepsy patients,and the combined detection of the two has higher predictive value.
EpilepsyZinc α2 glycoproteinHigh mobility group protein B1Predictive value