The relationship between the expression levels of serum Angptl4 and PPARγ and the prognosis of patients with acute ischemic stroke
Objective To explore the relationship between the expression levels of serum angiopoietin like protein 4(Angptl4),per-oxisome proliferator activated receptor γ(PPARγ)and the prognosis of patients with acute ischemic stroke.Methods A total of 100 patients with acute ischemic stroke admitted to Cangzhou Central Hospital from February 2020 to June 2022 were collected as the study group,and according to the severity of the condition evaluated by the National Institutes of Health Stroke Scale(NIHSS),the pa-tients were assigned into mild group(n=33,NIHSS score<6 points),moderate group(n=39,6 points≤NIHSS score<14 points),and se-vere group(n=28,NIHSS score≥14 points).According to the prognostic condition evaluated by modified Rankin scale(mRs)90 days after treatment,the patients were grouped into a good prognosis group(n=68,0-2 points)and a poor prognosis group(n=32,≥3 points);another 100 healthy volunteers from the same period were collected as the control group.Enzyme-linked immunosorbent assay(ELISA)was applied to detect the expression levels of Angptl4 and PPARγ in serum,which were compared between groups;multivariate logistic regression was applied to analyze the influencing factors for the prognosis of patients with acute ischemic stroke;receiver operating characteristic(ROC)curve was applied to analyze the prognostic evaluation value of serum Angptl4 and PPARγ.Results The expres-sion levels of Angptl4[(14.16±3.28)μg/L vs.(11.52±2.36)μg/L]and PPARγ[(38.54±9.63)ng/L vs.(26.68±7.48)ng/L]in the study group were higher than those in the control group(P<0.05).The expression levels of Angptl4 and PPARγ in the serum of the severe group were higher than those of the mild and moderate groups,with the moderate group higher than the mild group(P<0.05).Age,Ang-ptl4,PPARγ,proportion of hypertension,proportion of diabetes,NIHSS score at admission in the poor prognosis group were obviously higher than those in the good prognosis group(P<0.05).Serum Angptl4,PPARγ,and NIHSS scores were influencing factors for the prognosis of acute ischemic stroke patients(P<0.05).The area under the curve(AUC)of the combined evaluation of serum Angptl4 and PPARγ for the prognosis of acute ischemic stroke patients was 0.98.Conclusion Acute ischemic stroke patients with high expression levels of serum Angptl4 and PPARγ have more severe condition and worse prognosis.Serum Angptl4 and PPARγ are prognostic factors for patients with acute ischemic stroke,which can effectively evaluate the prognosis of patients.
StrokeBrain infarctionAngiopoietin-like protein 4Peroxisome proliferator activated receptor γPrognosis
万方数据
维普
