The effect of microwave thermocoagulation and local irradiation therapy on anti-tuberculosis treatment of laryngeal tuberculosis
Objective To observe the effect of microwave thermocoagulation and local irradiation on anti-tuberculosis treatment of la-ryngeal tuberculosis.Methods A total of 42 patients who were treated with standardized 2HRZE/4HR anti-tuberculosis regimen at Hebei Chest Hospital from October 2018 to September 2022 were selected as the treatment group,and they were treated with micro-wave thermocoagulation and local irradiation.In addition,42 patients who were treated with standardized 2HRZE/4HR anti-tuberculo-sis regimen alone during the same period were selected as the control group,and both groups were treated for 6 months.The sputum negative conversion rate and clinical symptom improvement time of the two groups were observed at 2,3 and 6 months after treatment.The changes of inflammatory indexes[γ-interferon(IFN-γ),tumor necrosis factor-α(TNF-α),interleukin-2(IL-2)]before treatment and 6 months after treatment were compared between the two groups.The incidence of adverse reactions during treatment was recorded in the two groups.Results The sputum negative conversion rate of the treatment group was higher than that of the control group at 2,3 and 6 months of treatment(32.50%,55.00%,95.00%vs.12.50%,32.50%,77.50%,P<0.05).The improvement time of hoarseness[(9.50±1.26)d vs.(10.85±1.69)d],pharyngeal discomfort/pain[(5.88±1.30)d vs.(7.73±1.50)d]and cough symptoms[(11.50±2.26)d vs.(13.25±2.31)d]in the treatment group was shorter than that in the control group(P<0.05).After 6 months of treatment,the levels of IFN-γ,TNF-α,and IL-2 in both groups decreased,and the treatment group was lower than the control group(P<0.05).The incidence of vari-ous adverse reactions in the treatment group was slightly lower than that in the control group,but the difference was not statistically sig-nificant(P>0.05).Conclusion Microwave thermocoagulation and local irradiation in the treatment of laryngeal nuclear energy signifi-cantly shortens the time for clinical symptom improvement in patients,increases sputum negative conversion rate,reduces the level of inflammatory indicators in the body,and is safe and reliable.
万方数据
维普
