The mechanism of Sanhuang decoction in treating hemorrhoids with damp-heat based on molecular docking
Objective The mechanism of Sanhuang decoction in treating hemorrhoids with damp-heat was analyzed based on net-work pharmacology and molecular docking.Methods The active ingredients in Sanhuang decoction were retrieved,the gene targets were screened,the common targets of Sanhuang decoction and hemorrhoids were enriched by Kyoto Encyclopedia of Genes and Ge-nomes(KEGG),and the drug-active ingredient-target network of Sanhuang decoction was constructed.Finally,affinity between the ac-tive ingredients and key targets was verified by molecular docking.Results A total of 25 potential targets and 5 active components of Sanhuang decoction and damp-heat hemorrhoids were screened using TCMSP database.Network pharmacological analysis results showed that epigberine,p-Coumaric acid,β-sitosterol,catechin,6-methoxynaringin could act on the five key core targets,NOS2,CAT,ALB,AKT1 and ESR1,and play a role in the treatment of hemorrhoids through thyroid hormone signaling pathway and sphingolipid sig-naling pathway.Molecular docking analysis results showed that five core active components of Sanhuang decoction had high binding activity with five key targets.Conclusion Sanhuang decoction mainly treats hemorrhoids through multi-component,multi-target,and multi-pathway process,in which NOS2,CAT,ALB,AKT1 and ESR1 are the main gene targets of Sanhuang decoction in treating hem-orrhoids with damp-heat.
HemorrhoidsMolecular docking technologyNetwork pharmacological analysisSanhuang decoctionSyndrome of dampness-heat diffusing downward
万方数据
维普
