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基于数据挖掘探究虫类药治疗结直肠癌的用药规律

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目的 借助数据挖掘方法探究虫类药治疗结直肠癌的处方用药规律,为结直肠癌的临床治疗及新药研发提供思路.方法 检索并筛选中国知网、万方数据库、维普数据库及中国生物医学文献数据库中从建库至2023年6月收录的含虫类中药处方治疗结直肠癌的文献,通过Microsoft office Excel 2019、IBM SPSS Modeler 18.0软件进行数据挖掘.结果 最终纳入治疗结直肠癌的含虫类处方234首,其中虫类药有34味;使用频次前6位的虫类药依次为鸡内金、蜈蚣、穿山甲、全蝎、阿胶、鳖甲;虫类药多与补虚药、清热药、理气药、消食药等配伍使用.结论 含虫类处方治疗结直肠癌常用鸡内金、蜈蚣、穿山甲、全蝎、阿胶、鳖甲等虫类药,常与健脾益气、利水渗湿、消食和胃之品配伍使用.
Exploration on the medication rules of insect drugs in treating colorectal cancer based on data mining technology
Objective To explore the prescription regularity of insect drugs in the treatment of colorectal cancer with the help of data mining technology,so as to provide some ideas for clinical treatment and new drug development of colorectal cancer.Methods Docu-ments on the treatment of colorectal cancer with insect-containing TCM prescriptions collected from CNKI,Wanfang Database,VIP da-tabase and China Biomedical Literature Database from the date available to June 2023 were retrieved and filtered.Data mining was conducted by Microsoft office Excel 2019 and IBM SPSS Modeler 18.0.Results A total of 234 insect-containing prescriptions were ul-timately included,including 34 types of insect drugs.The top 6 insect drugs used frequently were endothelium corneum gigeriae galli,centipede,pangolin scales,scorpion,donkey-hide gelatin,and turtle carapace,respectively.Insect drugs were mostly used in combina-tion with deficiency tonic medicine,heat clearing medicine,qi regulating medicine,and digestion medicine,etc.Conclusion Insect-containing TCM prescriptions commonly used in the treatment of colorectal cancer usually contain endothelium corneum gigeriae galli,centipede,pangolin scales,scorpion,donkey-hide gelatin,and turtle carapace,which were often used in combination with drugs that achieve the effects of invigorating spleen and qi,clearing water and dampness,helping digestion and harmonizing the stomach.

Animal medicineColorectal neoplasmsData miningMedication rule

郑拓拓、樊志敏

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南京中医药大学附属南京中医院肛肠科,江苏 南京 210022

江苏省中医肛肠疾病临床医学创新中心,江苏 南京 210022

南京中医肛肠疾病临床医学研究中心,江苏 南京 210022

动物药 结直肠肿瘤 数据挖掘 用药规律

2025

安徽医药
安徽省药学会

安徽医药

影响因子:1.941
ISSN:1009-6469
年,卷(期):2025.29(2)