首页|急性A型主动脉夹层患者发生院内死亡的危险因素分析

急性A型主动脉夹层患者发生院内死亡的危险因素分析

Analysis of Risk Factors for in-Hospital Death in Patients with Type A Aortic Dissection

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目的:探讨急性A型主动脉夹层(ATAAD)患者发生院内死亡的危险因素.方法:选取2018年1月-2022年12月于宜昌市中心人民医院就诊的288例ATAAD患者,根据患者预后情况分为院内死亡组(n=30)和生存组(n=258),将单因素分析中P<0.05的指标作为自变量,将患者院内死亡作为因变量,进行多因素Logistic回归分析,探讨ATAAD患者发生院内死亡的危险因素.结果:单因素分析结果显示,两组患者的年龄、心率、白细胞计数(WBC)、谷草转氨酶(AST)、谷丙转氨酶(ALT)、肌酸激酶同工酶(CK-MB)、促甲状腺素(TSH)水平差异有统计学意义(均P<0.05);多因素 Logistic 回归分析结果显示,年龄 ≥60 岁(OR=2.807,95%CI:2.341,3.365)、WBC>10× 109/L(OR=2.837,95%CI:2.360,3.410)、ALT≥40 U/L(OR=3.081,95%CI:2.525,3.760)均为ATAAD院内死亡的独立危险因素(均P<0.05).结论:年龄≥60岁、WBC>10×109/L、ALT≥40 U/L均为ATAAD患者发生院内死亡的独立危险因素.
Objective:To explore the risk factors for in-hospital death among patients with acute type A aortic dissection(ATAAD).Methods:A retrospective analysis was conducted on the medical records of 288 ATAAD patients admitted to Yichang Central People's Hospital from January 2018 to December 2022.The patients were divided into in-hospital death group(n=30)and survival group(n=258)based on their prognosis.Multivariate Logistic regression analysis was performed to identify risk factors for in-hospital death among ATAAD patients,with the independent variables being the factors with P<0.05 in the univariate analysis and the dependent variable being in-hospital death.Results:Univariate analysis showed significant differences in age,heart rate,white blood cell count(WBC),aspartate aminotransferase(AST),alanine aminotransferase(ALT),creatine kinase isoenzyme(CK-MB),and thyrotropin(TSH)levels between the two groups(all P<0.05).Multivariate Logistic regression analysis revealed that age≥60 years(OR=2.807,95%CI:2.341,3.365),WBC>10×109/L(OR=2.837,95%CI:2.360,3.410),and ALT≥40 U/L(OR=3.081,95%CI:2.525,3.760)were independent risk factors for in-hospital death of ATAAD(all P<0.05).Conclusion:Age≥60 years,WBC>10X109/L,and ALT≥40 U/L are independent risk factors for in-hospital death among ATAAD patients.

acute type A aortic dissection(ATAAD)in-hospital deathsurvivalrisk factors

杜真、席祖洋

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三峡大学第一临床医学院[宜昌市中心人民医院]心血管内科&三峡大学心血管疾病研究所,湖北宜昌 443003

三峡大学 临床护理研究中心,湖北 宜昌 443003

缺血性心血管病湖北省重点实验室,湖北宜昌 443003

湖北省缺血性心血管疾病临床医学研究中心,湖北宜昌 443003

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急性A型主动脉夹层 院内死亡 生存 危险因素

湖北省自然科学基金创新群体项目湖北省教育厅重点项目湖北省科技创新基地条件平台专项湖北省重点研发计划湖北省卫生健康委面上项目宜昌市医疗卫生研究项目

2022CFA015D202212052022DCC0142022BCE001WJ2023M151A23-1-020

2024

巴楚医学
三峡大学

巴楚医学

ISSN:2096-6113
年,卷(期):2024.7(2)