Objective:To explore the mechanism of epimedium in treating heart failure(HF)through network pharmacology and molecular docking technology.Methods:The effective active components of epimedium were screened through the traditional Chinese medicine systems pharmacology(TCMSP)database,and the potential therapeutic targets of HF were screened through the GeneCards database.Cytoscape software was used to construct a"drug-active ingredient-target-disease"network for the treatment of HF with epimedium.Protein interaction analysis and target enrichment analysis were performed using the String and Metascape databases.Molecular docking of key active components with core targets was performed using AutoDock software.Results:A total of 23 potentially effective active components and 70 potential targets for epimedium in the treatment of HF were obtained.Network analysis showed that epimedium may participate in biological processes such as inflammatory response,wound response,reactive oxygen metabolism,positive regulation of cell migration,and positive regulation of cell movement through hypoxia-inducible factor-1(HIF-1),T-cell receptor,p53,Ca2+and PPAR signaling pathway.Molecular docking prediction suggested that there were six main active ingredients in epimedium,with binding energy ranging from low to high as 8-(3-methylbut-2-enyl)-2-phenylchromone,luteolin,kaempferol,quercetin,anhydroicaritin and 8-isopentenylflavone.These active ingredients stably bound to the PTGS2 core target,thereby exerting a therapeutic effect on HF.Conclusion:This study preliminarily explored the treatment of HF by epimedium through multi-component,multi-target,and multi-pathway.
维普
万方数据
