Objective:To investigate the relationship between low level of hepatitis B virus surface antigen(HBsAg)in serum,HBV DNA load and liver function index.Methods:A total of 408 patients with low level HBsAg treated in Zhenhai District People's Hospital of Ningbo City from June 2020 to December 2021 were selected.Hepatitis B virus surface antibody(anti-HBs),hepatitis B virus e antigen(HBeAg),hepatitis B virus e antibody(anti-HBe)and hepatitis B virus core antibody(anti-HBc),HBV DNA load and liver function indicators were detected in all enrolled patients.Results:Among 408 patients with low level HBsAg,patients with positive anti-HBe and anti-HBc,and negative anti-HBs and HBeAg,accounted for the highest proportion(88.24％).A total of 82 cases(20.10％)were HBV DNA positive,and there was a significant difference in HBV DNA positive rate at different concentrations of HBsAg(P=0.041).When HBsAg concentration was between 31 and 40 COI,the HBV DNA positive rate was the highest(30.00％).There was no significant difference in HBV DNA load among different concentrations of HBsAg(P＞0.05).There was no significant difference in liver function of different concentrations of HBsAg and HBV DNA(both P＞0.05).Conclusion:In patients with low level HBsAg,the proportion of patients with positive anti-HBe/anti-HBc and negative anti-HBs/HBeAg is the highest.The positive rate of HBV DNA varies with different concentration of HBsAg,but it has no impact on HBV DNA load.HBsAg concentration and HBV DNA load have no impact on the liver function of low level HBsAg patients.
hepatitis B virus(HBV)hepatitis B virus surface antigen(HBsAg)HBV DNA loadliver function
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