Objective:To investigate the expression level and clinical significance of kallikrein 11(KLK11)in tumor tissue of patients with pancreatic ductal adenocarcinoma.Methods:A total of 152 patients with pancreatic ductal adenocarcinoma who underwent radical pancreatoduodenectomy at Yichang Central People's Hospital from January 2018 to December 2022 were selected.The clinical data of all included patients were collected,and the immunohistochemical results of low expression(n=65)and high expression(n=87)of KLK11 were analyzed,as well as their impact on the survival of patients.Furthermore,univariate and multivariate analyses were conducted using the Cox proportional hazards model to explore the independent influencing factors affecting the survival of patients with pancreatic ductal adenocarcinoma.Results:Immunohistochemical results showed that there were low and high expressions of KLK11 in pancreatic ductal adenocarcinoma tissues.The survival rate of patients with high KLK11 expression was significantly lower than that of patients with low KLK11 expression(P=0.003).Moderate-to-poor tumor differentiation(HR=3.447,95％CI:1.542,7.707),tumor size＞3.0 cm(HR=4.452,95％CI:2.094,9.465),TNM stage Ⅱ(HR=14.840,95％CI:5.284,41.680)/Ⅲ(HR=27.880,95％CI:9.419,82.550),portal vein invasion(HR=4.929,95％CI:1.395,17.421),and high KLK11 expression(HR=6.007,95％CI:2.270,15.895)were independent risk factors affecting the survival of patients with pancreatic ductal adenocarcinoma after surgery(all P＜0.05).Conclusion:Moderate-to-poor tumor differentiation,tumor size＞3.0 cm,TNM stage Ⅱ/m,portal vein invasion,and high KLK11 expression are independent risk factors affecting the survival of patients with pancreatic ductal adenocarcinoma after surgery.
维普
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