Vibrio parahaemolyticus(V.p)is a common bacterium in marine ecosystem and the main pathogen of infectious diarrhea in China.Its pathogenicity is closely related to virulence factors,especially thermostable direct hemolysin(TDH),TDH-related hemolysin(TRH)and Type Ⅲ secretion system-2(T3SS-2).Strains carrying virulence genes can cause vomiting,diarrhea,wound infection and sepsis in patients.Bile acid is a key factor in activating V.p virulence factor and sensing the host intestinal microenvironment,and plays an important role in digestion of food and antibacterial activity.Pathogenic V.p can sense bile acid and activate virulence factor to cause infection.This paper aims to analyze the bile acid-bacteria interaction,discuss how V.p senses bile acids,and discuss the mechanism of bile acids in regulating V.p virulence factors,and provide ideas for the development of potential new antibacterial therapies.
维普
万方数据
