首页|创伤性脊柱骨折患者术后下肢深静脉血栓形成的危险因素分析

创伤性脊柱骨折患者术后下肢深静脉血栓形成的危险因素分析

Analysis of Risk Factors for Postoperative Deep Vein Thrombosis in Patients with Traumatic Spinal Fractures

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目的:分析创伤性脊柱骨折患者术后下肢深静脉血栓形成(DVT)的独立危险因素.方法:回顾性分析2021年9月-2024年2月于宜昌市中心人民医院行创伤性脊柱骨折手术治疗的205例患者的临床资料.根据术后1周内下肢静脉超声检查结果,将患者分为DVT组(n=55)和非DVT组(n=150),采用单因素及多因素Logistic回归分析术后DVT发病的危险因素.结果:术后DVT的总发生率为26.83%(55/205),其中3例为近端血栓,52例为远端血栓.多因素Logistic回归分析显示,年龄增加(OR=1.120,95%CI:1.061,1.183),D-二聚体升高(OR=1.347,95%CI:1.112,1.633),卧床时间延长(OR=1.313,95%CI:1.137,1.516),低蛋白血症(OR=14.380,95%CI:3.957,52.263),输血(OR=5.707,95%CI:1.828,17.820)是创伤性脊柱骨折患者术后DVT的独立危险因素(均P<0.001).受试者工作特征(ROC)曲线分析结果显示,年龄增加、D-二聚体升高、卧床时间延长、低蛋白血症及输血的曲线下面积(AUC)值分别为0.734、0.884、0.822、0.777、0.760.通过约登指数确定术后D-二聚体、年龄、卧床时间的诊断截断值分别为3.185 mg/L、47.5岁、12.5天.结论:创伤性脊柱骨折术后DVT发生率高,年龄>47.5岁、D-二聚体>3.185 mg/L、卧床时间>12.5天、低蛋白血症及输血是创伤性脊柱骨折患者术后发生DVT的独立危险因素.
Objective:To analyze the independent risk factors for the development of deep venous thrombosis(DVT)in the lower extremities of patients after traumatic spinal fracture surgery.Methods:A retrospective analysis was conducted on the clinical data of 205 patients who underwent traumatic spinal fracture surgery in Yichang Central People's Hospital from September 2021 to February 2024.Based on the results of lower extremity venous ultrasound examination within 1 week after surgery,the patients were divided into the DVT group(n=55)and the non-DVT group(n=150).Univariate and multivariate Logistic regression analyses were used to identify the risk factors for the development of postoperative DVT.Results:The overall incidence of postoperative DVT was 26.83%(55/205),including 3 cases of proximal thrombosis and 52 cases of distal thrombosis.Multivariate Logistic regression analysis showed that increased age(OR=1.120,95%CI:1.061,1.183),elevated D-dimer(OR=1.347,95%CI:1.112,1.633),prolonged bed rest(OR=1.313,95%CI:1.137,1.516).hypoproteinemia(OR=14.380,95%CI:3.957,52.263),and blood transfusion(OR=5.707,95%CI:1.828,17.820)were independent risk factors for the development of postoperative DVT in patients with traumatic spinal fractures(all P<0.001).Receiver operating characteristic(ROC)curve analysis showed that the area under the curve(AUC)values for increased age,elevated D-dimer,prolonged bed rest,hypoproteinemia,and blood transfusion were 0.734,0.884,0.822,0.777,and 0.760,respectively.The diagnostic cutoff values for postoperative D-dimer,age,and bed rest were determined using the Youden index,which were 3.185 mg/L,47.5 years,and 12.5 days.Conclusion:The incidence of DVT after traumatic spinal fracture surgery is high,and age>47.5 years,D-dimer>3.185 mg/L,bed rest>12.5 days,hypoproteinemia,and blood transfusion are independent risk factors for the development of DVT in patients with traumatic spinal fractures surgery.

spinal fracturedeep vein thrombosis(DVT)risk factorsD-dimer

杨调、陈世文、卓灿、刘正强、周振宇、陈海丹

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三峡大学第一临床医学院[宜昌市中心人民医院]脊柱外科,湖北宜昌 443003

宁夏医科大学骨科,宁夏银川 750004

脊柱骨折 深静脉血栓形成 危险因素 D-二聚体

国家自然科学基金项目湖北省自然科学基金项目

813023462024AFD130

2024

巴楚医学
三峡大学

巴楚医学

ISSN:2096-6113
年,卷(期):2024.7(3)