Objective:To observe the clinical efficacy of epidural anesthesia in patients with hip arthroplasty.Methods:A total of 80 patients with hip arthroplasty hospitalized in Wuhan Orthopaedic Hospital of Integrated Traditional Chinese and Western Medicine from May 2020 to November 2021 were selected and divided into an observation group(n=40)and a control group(n=40)based on different anesthesia methods.The control group received general anesthesia,while the observation group received epidural anesthesia.The perioperative indicators of the two different anesthesia methods were comparatively analyzed,including activated partial thromboplastin time(APTT),prothrombin time(PT),D-dimer(D-D),fibrinogen(FIB),serum amyloid A protein(Aβ),neuronal microtubule-associated protein(Tau),etc.Results:The time to regain consciousness[(8.13±2.42)min vs(11.26±3.34)min],hospital stay[(7.44±2.28)days vs(10.82±2.31)days],and plasma cholinesterase(CHE)normalization time[(6.76±1.23)days vs(8.39±2.27)days]in the observation group were significantly shorter(all P＜0.05).Six hours after anesthesia,the PT[(12.47±0.92)s vs(13.35±0.84)s]and APTT[(29.56±1.49)s vs(33.15±1.79)s]of the observation group decreased,while D-D[(1.75±0.47)μg/mL vs(1.33±0.45)μg/mL]and FIB[(5.13±1.05)g/mL vs(4.56±1.04)g/mL]increased(all P＜0.05).One day after surgery,the Aβ[(532.26±119.85)g/L vs(789.67±135.48)g/L],Tau[(76.83±8.68)ng/L vs(89.28±9.56)ng/L],and P-Tau[(82.23±9.31)pg/mL vs(91.44±9.72)pg/mL]of the observation group were significantly lower(all P＜0.05).Conclusion:Epidural anesthesia can improve perioperative-related indicators after surgery,improve coagulation function,improve cognitive function,and has good clinical efficacy,worthy of further promotion and application.
epidural anesthesiahip arthroplastycoagulation functioncognitive function
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