Objective:To explore the effectiveness and safety of temporary cardiac pacemaker implantation via the median cubital vein.Methods:This study included 49 patients who underwent temporary cardiac pacemaker implantation at Yidu Hospital of Traditional Chinese Medicine from August 2020 to April 2024.The patients were randomly divided into a control group(n=25)and an observation group(n=24)according to the venous access route.The control group received the traditional route(implantation via the femoral vein),while the observation group received the median cubital vein route.The clinical efficacy of the two groups was compared.Results:Compared with the control group,the time for puncture and catheterization[(1.67±2.24)min vs(4.87±1.28)min],radiation dose[(13.07±3.92)mGy vs(15.63±4.65)mGy]in the observation group were significantly lower,the general comfort questionnaire score(66.04±3.12)vs(52.23±4.56)was significantly higher,and there was no significant difference in the incidence of postoperative complications between the two groups of patients(P>0.05).Conclusion:Temporary cardiac pacemaker implantation via the median cubital vein is safe and effective,which is worthy of clinical promotion and application.