Objective:Guided by the traditional Chinese medicine concept of"treating different diseases with the same method,"this study utilizes network pharmacology and molecular docking techniques to analyze the pharmacological mechanisms of action of Xintong preparations in the treatment of coronary heart disease and diabetes.Methods:The chemical components of the Xintong preparation were retrieved from the Traditional Chinese Medicine Systems Pharmacology(TCMSP)database and literature searches.Drug targets were obtained using SwissTargetPrediction,and targets for coronary heart disease and diabetes were retrieved from the GeneCards database and TTD database.The"drug-component-target"network diagram was constructed using Cytoscape 3.9.1.The protein-protein interaction(PPI)network was constructed using the STRING database,and Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses were performed using the DAVID database.Finally,molecular docking was conducted.Results:A total of 90 potential active ingredients were screened out for the treatment of coronary heart disease and diabetes by Xintong preparations,corresponding to 121 targets.Analysis of the drug-component-target network diagram identified the main active components,including quercetin,astragaloside Ⅳ,emodin,icariin,and ferulic acid.PPI network analysis identified key targets,including signal transducer and activator of transcription 3(STAT3),tumor protein p53(TP53),tumor necrosis factor(TNF),serine/threonine-protein kinase 1(AKT1),interleukin-6(IL-6),and vascular endothelial growth factor A(VEGFA).Molecular docking results showed that the key components had good binding capabilities with the core targets.Conclusion:Multiple active components in Xintong preparations exert the effects of"treating different diseases with the same method"for coronary heart disease and diabetes through multiple targets and pathways,providing new insights and theoretical basis for further experimental and clinical research.
same treatment of different diseaseXintong preparationcoronary heart diseasediabetes mellitusnetwork pharmacology
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