Objective:To analyze the screening and prognosis of latent tuberculosis infection(LTBI)in children with different systemic diseases.Methods:A retrospective study was conducted to collect 484 children who underwent tuberculosis infection T-cell spot test(T-SPOT.TB)at Yichang Central People's Hospital from January 2018 to April 2022.The children were divided into T-SPOT positive group(n=27)and T-SPOT negative group(n=457)based on the results of T-SPOT.TB examination,and the included children were followed up and observed.Results:Among the 484 children screened for LTBI,27 were positive,with a total positive rate of 5.58％.There were statistical differences between the two groups in different systemic diseases and whether they were tuberculosis patients(both P＜0.05).The highest proportion of children in both groups was respiratory system diseases(59.26％and 79.65％).Among children with different systemic diseases,the T-SPOT positive rate was highest in blood system disease and tumor(23.81％),followed by lymphatic system(14.29％),nervous system(7.69％),digestive system(6.67％),respiratory system(4.21％),and rheumatologic immune system(3.70％).Nine children were diagnosed with tuberculosis,and there was no significant difference in whether they were in close contact with tuberculosis patients and related blood indicators between tuberculosis patients and non-tuberculosis patients(both P＜0.05).Conclusion:Children with blood system disease and tumor,lymphatic,nervous,and digestive system diseases have higher detection rates of LTBI than those with respiratory and rheumatologic immune system diseases.These children need to actively undergo LTBI screening.
Mycobacterium tuberculosislatent tuberculosis infection(LTBI)screeningT cell spot test for tuberculosis infection(T-SPOT.TB)
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